MAP3K8

Gene Symbol MAP3K8
Entrez Gene 1326
Alt Symbol AURA2, COT, EST, ESTF, MEKK8, TPL2, Tpl-2, c-COT
Species Human
Gene Type protein-coding
Description mitogen-activated protein kinase kinase kinase 8
Other Description Ewing sarcoma transformant|augmented in rheumatoid arthritis 2|cot (cancer Osaka thyroid) oncogene|proto-oncogene c-Cot|proto-oncogene serine/threoine protein kinase|tumor progression locus 2
Swissprots D3DRX1 P41279 Q9HC81 Q14275 Q5T855 A8K2Q5
Accessions AAP45053 EAW86004 EAW86005 EAW86006 EAW86007 P41279 AA156603 AB209539 BAD92776 AK290320 BAF83009 AK313295 BAG36102 AL547407 BC022398 BC104833 AAI04834 BC113566 AAI13567 BR000407 FAA00321 CR542284 CAG47079 D14497 BAA03387 DA308072 DB271664 HQ258255 ADR83009 Z14138 CAA78512 XM_005252364 XP_005252421 XM_011519308 XP_011517610 XM_011519309 XP_011517611 XM_011519310 XP_011517612 XM_011519311 XP_011517613 XM_011519312 XP_011517614 XM_011519313 XP_011517615 XM_011519314 XP_011517616 XM_011519315 XP_011517617 NM_001244134 NP_001231063 NM_005204 NP_005195
Function Required for lipopolysaccharide (LPS)-induced, TLR4- mediated activation of the MAPK/ERK pathway in macrophages, thus being critical for production of the proinflammatory cytokine TNF- alpha (TNF) during immune responses. Involved in the regulation of T-helper cell differentiation and IFNG expression in T-cells. Involved in mediating host resistance to bacterial infection through negative regulation of type I interferon (IFN) production. In vitro, activates MAPK/ERK pathway in response to IL1 in an IRAK1-independent manner, leading to up-regulation of IL8 and CCL4. Transduces CD40 and TNFRSF1A signals that activate ERK in B- cells and macrophages, and thus may play a role in the regulation of immunoglobulin production. May also play a role in the transduction of TNF signals that activate JNK and NF-kappa-B in some cell types. In adipocytes, activates MAPK/ERK pathway in an IKBKB-dependent manner in response to IL1B and TNF, but not insulin, leading to induction of lipolysis. Plays a ro
Subcellular Location Cytoplasm {ECO:0000269|PubMed:1833717, ECO:0000269|PubMed:8226782}.
Tissue Specificity Expressed in several normal tissues and human tumor-derived cell lines.
Top Pathways Toll-like receptor signaling pathway, T cell receptor signaling pathway, MAPK signaling pathway, TNF signaling pathway

MAP3K8 overexpression lysate - LY401593 from Acris Antibodies

Category Cell Lysate
Prices $280.00
Sizes 100 µg

MAP3K8 293 Cell Lysate - 401443 from ABBIOTEC

Category Cell Lysate
Prices $392.00
Sizes 100 µg

MAP3K8/Tpl2/COT Overexpression Lysate (Native) - NBL1-12859 from Novus Biologicals

Category Cell Lysate
Prices $329.00
Sizes 100 µg

MAP3K8 Over-expression Lysate Product - GWB-5574B9 from Genway Biotech

Category Cell Lysate
Prices $346.00
Sizes 100 µg
Species Human

Human TPL2 / MAP3K8 / MEKK8 Insect Cell Lysate (WB positive control) - 10800-H09BL-300 from Sino Biological

Category Cell Lysate
Prices $195.00
Sizes 300 µg
Species Human

Human MAP3K8 Baculovirus-Insect Cells Transfected Lysate (positive control) (denatured) - orb175001 from Biorbyt

Category Cell Lysate
Prices $604.00
Sizes 300 μg
Species Human

Panoply™ Human MAP3K8 Knockdown Stable Cell Line - CSC-DC009178 from Creative biogene

Category Cell Line
Species Human

Human MAP3K8 Knockout Cell Line-HeLa - CSC-RT0705 from Creative biogene

Category Cell Line
Species Human

Human MAP3K8 Knockout Cell Line-HeLa - CSC-RT1253 from Creative biogene

Category Cell Line
Species Human

MAP3K8 KO Cell Lysate-HeLa - CLKO-0210 from Creative biogene

Category Cell Lysate

MAP3K8 KO Cell Lysate-HeLa - CLKO-1106 from Creative biogene

Category Cell Lysate
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