MAP3K8

Gene Symbol MAP3K8
Entrez Gene 1326
Alt Symbol AURA2, COT, EST, ESTF, MEKK8, TPL2, Tpl-2, c-COT
Species Human
Gene Type protein-coding
Description mitogen-activated protein kinase kinase kinase 8
Other Description Ewing sarcoma transformant|augmented in rheumatoid arthritis 2|cot (cancer Osaka thyroid) oncogene|proto-oncogene c-Cot|proto-oncogene serine/threoine protein kinase|tumor progression locus 2
Swissprots D3DRX1 P41279 Q9HC81 Q14275 Q5T855 A8K2Q5
Accessions AAP45053 EAW86004 EAW86005 EAW86006 EAW86007 P41279 AA156603 AB209539 BAD92776 AK290320 BAF83009 AK313295 BAG36102 AL547407 BC022398 BC104833 AAI04834 BC113566 AAI13567 BR000407 FAA00321 CR542284 CAG47079 D14497 BAA03387 DA308072 DB271664 HQ258255 ADR83009 Z14138 CAA78512 XM_005252364 XP_005252421 XM_011519308 XP_011517610 XM_011519309 XP_011517611 XM_011519310 XP_011517612 XM_011519311 XP_011517613 XM_011519312 XP_011517614 XM_011519313 XP_011517615 XM_011519314 XP_011517616 XM_011519315 XP_011517617 NM_001244134 NP_001231063 NM_005204 NP_005195
Function Required for lipopolysaccharide (LPS)-induced, TLR4- mediated activation of the MAPK/ERK pathway in macrophages, thus being critical for production of the proinflammatory cytokine TNF- alpha (TNF) during immune responses. Involved in the regulation of T-helper cell differentiation and IFNG expression in T-cells. Involved in mediating host resistance to bacterial infection through negative regulation of type I interferon (IFN) production. In vitro, activates MAPK/ERK pathway in response to IL1 in an IRAK1-independent manner, leading to up-regulation of IL8 and CCL4. Transduces CD40 and TNFRSF1A signals that activate ERK in B- cells and macrophages, and thus may play a role in the regulation of immunoglobulin production. May also play a role in the transduction of TNF signals that activate JNK and NF-kappa-B in some cell types. In adipocytes, activates MAPK/ERK pathway in an IKBKB-dependent manner in response to IL1B and TNF, but not insulin, leading to induction of lipolysis. Plays a ro
Subcellular Location Cytoplasm {ECO:0000269|PubMed:1833717, ECO:0000269|PubMed:8226782}.
Tissue Specificity Expressed in several normal tissues and human tumor-derived cell lines.
Top Pathways Toll-like receptor signaling pathway, T cell receptor signaling pathway, MAPK signaling pathway, TNF signaling pathway

Cot CRISPR/Cas9 KO Plasmid (h) - sc-417713 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

Cot HDR Plasmid (h) - sc-417713-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

Cot Double Nickase Plasmid (h) - sc-417713-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

Cot Double Nickase Plasmid (h2) - sc-417713-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

Cot CRISPR Activation Plasmid (h) - sc-417713-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

Cot CRISPR Activation Plasmid (h2) - sc-417713-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

Cot Lentiviral Activation Particles (h) - sc-417713-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

Cot Lentiviral Activation Particles (h2) - sc-417713-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

Cot siRNA (h) - sc-35095 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

Cot shRNA Plasmid (h) - sc-35095-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

Cot shRNA (h) Lentiviral Particles - sc-35095-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

MAP3K8/Tpl2/COT RNAi - H00001326-R02 from Novus Biologicals

Category siRNA
Prices $399.00
Sizes 20 nmol
Species Reactivities Human

MISSION® esiRNA - EHU051991 from Sigma-Aldrich

Category siRNA
Prices $250.00
Sizes 50 µg

MISSION® siRNA - SIHK1159 from Sigma-Aldrich

Category siRNA
Prices $25.00
Sizes 0.25 nmol

MISSION® siRNA - SIHK1160 from Sigma-Aldrich

Category siRNA
Prices $25.00
Sizes 0.25 nmol

MISSION® siRNA - SIHK1161 from Sigma-Aldrich

Category siRNA
Prices $25.00
Sizes 0.25 nmol

CompoZr® Knockout ZFN Kit - CKOZFN12996 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND12996 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

MISSION® 3′UTR Lenti GoClone™ - HUTR07541 from Sigma-Aldrich

Category miRNA
Prices $350.00
Sizes hutr07541

MAP3K8 siRNA (Human) - CRH0931 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

shRNA set against Human MAP3K8 (NM_005204.3) - SHH337763 from Creative biogene

Category siRNA
Species Reactivities Human

MAP3K8 shRNA Plasmid (Human) - CHH0931 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human

MAP3K8 miRNA 3'UTR clone - MiUTR1H-06069 from Creative biogene

Species Reactivities Human

MAP3K8 miRNA 3'UTR clone - MiUTR3H-02334 from Creative biogene

Species Reactivities Human
Search more