SP1

Gene Symbol	SP1
Entrez Gene	6667
Alt Symbol	-
Species	Human
Gene Type	protein-coding
Description	Sp1 transcription factor
Other Description	specificity protein 1|transcription factor Sp1
Swissprots	Q9NY21 Q9H3Q5 E4Z9M7 Q9NR51 P08047 Q86TN8 Q9NYE7 G5E9M8
Accessions	AAF75063 AAF78780 BAB13476 CAP12210 CCQ43200 EAW96698 EAW96699 EAW96700 P08047 AB209678 BAD92915 AF252284 AAF67726 AF255682 AAF78781 AI282745 AI561005 AJ272134 CAB75345 AK311995 BAG34933 AL442093 AW028976 BC012008 BC043224 AAH43224 BC062539 AAH62539 BC078158 BF434304 BF436290 BF671559 BM463205 BQ072120 BQ431320 BQ774060 CD104746 FJ949572 ACR22508 FN908228 CBM42955 J03133 AAA61154 XM_011538696 XP_011536998 NM_001251825 NP_001238754 NM_003109 NP_003100 NM_138473 NP_612482
Function	Transcription factor that can activate or repress transcription in response to physiological and pathological stimuli. Binds with high affinity to GC-rich motifs and regulates the expression of a large number of genes involved in a variety of processes such as cell growth, apoptosis, differentiation and immune responses. Highly regulated by post-translational modifications (phosphorylations, sumoylation, proteolytic cleavage, glycosylation and acetylation). Binds also the PDGFR- alpha G-box promoter. May have a role in modulating the cellular response to DNA damage. Implicated in chromatin remodeling. Plays a role in the recruitment of SMARCA4/BRG1 on the c-FOS promoter. Plays an essential role in the regulation of FE65 gene expression. In complex with ATF7IP, maintains telomerase activity in cancer cells by inducing TERT and TERC gene expression. Isoform 3 is a stronger activator of transcription than isoform 1. Positively regulates the transcription of the core clock component ARNTL/
Subcellular Location	Nucleus. Cytoplasm. Note=Nuclear location is governed by glycosylated/phosphorylated states. Insulin promotes nuclear location, while glucagon favors cytoplasmic location.
Tissue Specificity	Up-regulated in adenocarcinomas of the stomach (at protein level). Isoform 3 is ubiquitously expressed at low levels. {ECO:0000269|PubMed:21798247}.
Top Pathways	TGF-beta signaling pathway, Huntington's disease, Estrogen signaling pathway, Choline metabolism in cancer, Transcriptional misregulation in cancer

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human SP1 (phospho T453) peptide - ab38350 from Abcam Category Peptide

Human SP1 full length protein - ab82236 from Abcam Category Protein Source Baculovirus Species Human

Human SP1 peptide - ab42654 from Abcam Category Peptide

Human SP1 peptide - ab98897 from Abcam Category Peptide

Human SP1 protein fragment - ab81801 from Abcam Category Protein Source E. coli Species Human

Human SP1 protein fragment - ab92257 from Abcam Category Protein Source E. coli Species Human

SP1-Antibody-C-term-P692-Blocking-peptide - BP11451b from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

SP1 blocking peptide - GTX89511-PEP from GeneTex Category Peptide Prices $239.00 Sizes 100 μg Species Human, Mouse, Dog, Pig, Rat, Bovine

SP1 Peptide - orb224206 from Biorbyt Category Peptide Prices $272.00, $510.00 Sizes 1 mg, 5 mg Species Human, Mouse, Rat, Monkey, Cat

Human Specificity Protein 1 Protein - abx069140 from Abbexa Category Protein Source E.coli Species Human

SP1 Peptide - AC21-0739-P from Abcore Category Peptide Prices $160.00 Sizes 100 µg

SP1 / TSFP1 - H00006667-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

SP1 / TSFP1 - H00006667-Q01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

Specificity Protein 1 (Sp1), Human - 20-9525 from ARP American Research Products Category Protein Prices $489.00 Sizes 50 µg Source E.coli Species Human

SP1 Peptide - 45-151P from ProSci Category Peptide Prices $175.00 Sizes 100 µg Species Human, Mouse

SP1 fusion protein - ag17828 from Proteintech Group Category Protein Source E. coli-derived, PET28a Species Human

SP1 fusion protein - ag16720 from Proteintech Group Category Protein Source E. coli-derived, PGEX-4T Species Human

Recombinant Human Sp1 Transcription Factor, GST-tagged - SP1-1159H from Creative Biomart Category Protein Source E. coli.

Recombinant Human Sp1 Transcription Factor - SP1-590H from Creative Biomart Category Protein Source Sf9 insect cells.

Recombinant Human SP1, HA & Flag-tagged - SP1-2093H from Creative Biomart Category Protein Source Insect cells Species Human

Recombinant Human SP1 - SP1-30608TH from Creative Biomart Category Protein Source E. coli

Recombinant Human SP1, His-tagged - SP1-30697TH from Creative Biomart Category Protein

Recombinant Human SP1, His-tagged - SP1-30987TH from Creative Biomart Category Protein Source E. coli

Recombinant Human SP1, His-tagged - SP1-8472H from Creative Biomart Category Protein Source Sf21 Cells Species Human

Recombinant Human SP1, GST-tagged - SP1-8511H from Creative Biomart Category Protein Source E. coli Species Human

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