| Gene Symbol | Dpp4 |
|---|---|
| Entrez Gene | 13482 |
| Alt Symbol | Cd26, Dpp-4, THAM |
| Species | Mouse |
| Gene Type | protein-coding |
| Description | dipeptidylpeptidase 4 |
| Other Description | DPP IV|T-cell activation antigen CD26|dipeptidyl peptidase 4|dipeptidyl peptidase IV|thymocyte-activating molecule |
| Swissprots | Q3U514 P28843 |
| Accessions | AAA82213 EDL26985 EDL26986 P28843 AK040409 AK085370 BAC39434 AK153591 AK153939 BAE32266 AK163085 BAE37187 AK164775 BC022183 AAH22183 X58384 CAA41274 XM_006498691 XP_006498754 XM_006498692 XP_006498755 XM_006498693 XP_006498756 XM_011239274 XP_011237576 NM_001159543 NP_001153015 NM_010074 NP_034204 |
| Function | Cell surface glycoprotein receptor involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T-cell activation. Acts as a positive regulator of T-cell coactivation, by binding at least ADA, CAV1, IGF2R, and PTPRC. Its binding to CAV1 and CARD11 induces T-cell proliferation and NF- kappa-B activation in a T-cell receptor/CD3-dependent manner. Its interaction with ADA also regulates lymphocyte-epithelial cell adhesion. In association with FAP is involved in the pericellular proteolysis of the extracellular matrix (ECM), the migration and invasion of endothelial cells into the ECM. May be involved in the promotion of lymphatic endothelial cells adhesion, migration and tube formation. When overexpressed, enhanced cell proliferation, a process inhibited by GPC3. Acts also as a serine exopeptidase with a dipeptidyl peptidase activity that regulates various physiological processes by cleaving peptides in the circulation, including many chemokines, mitogenic growth fact |
| Subcellular Location | Dipeptidyl peptidase 4 soluble form: Secreted. Note=Detected in the serum and the seminal fluid. {ECO:0000250}. |
| Top Pathways | Protein digestion and absorption |
CD26 CRISPR/Cas9 KO Plasmid (m) - sc-420048 from Santa Cruz Biotechnology
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CD26 HDR Plasmid (m) - sc-420048-HDR from Santa Cruz Biotechnology
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CD26 Double Nickase Plasmid (m) - sc-420048-NIC from Santa Cruz Biotechnology
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CD26 Double Nickase Plasmid (m2) - sc-420048-NIC-2 from Santa Cruz Biotechnology
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CD26 CRISPR Activation Plasmid (m) - sc-420048-ACT from Santa Cruz Biotechnology
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CD26 CRISPR Activation Plasmid (m2) - sc-420048-ACT-2 from Santa Cruz Biotechnology
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CD26 Lentiviral Activation Particles (m) - sc-420048-LAC from Santa Cruz Biotechnology
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CD26 Lentiviral Activation Particles (m2) - sc-420048-LAC-2 from Santa Cruz Biotechnology
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CD26 siRNA (m) - sc-42763 from Santa Cruz Biotechnology
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CD26 shRNA Plasmid (m) - sc-42763-SH from Santa Cruz Biotechnology
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CD26 shRNA (m) Lentiviral Particles - sc-42763-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EMU045721 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN30203 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND30203 from Sigma-Aldrich
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DPP4 siRNA (Mouse) - CRM1074 from Cohesion Biosciences
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DPP4 - MBS8207242 from MyBioSource
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shRNA set against Mouse DPP4 (NM_010074.3) - SHH280669 from Creative biogene
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Mouse DPP4 siRNA - orb280550 from Biorbyt
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DPP4 shRNA Plasmid (Mouse) - CHM1074 from Cohesion Biosciences
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