| Gene Symbol |
Crbn
|
| Entrez Gene |
58799
|
| Alt Symbol |
2610203G15Rik, 2900045O07Rik, AF229032, AW108261, piL
|
| Species |
Mouse
|
| Gene Type |
protein-coding
|
| Description |
cereblon
|
| Other Description |
novel lethal|protein PiL|protein cereblon
|
| Swissprots |
Q80XJ1 Q6IS49 Q8C6B7 Q8BP45 Q5RJV6 Q8C7D2 Q3TVC2 Q9JKR4
|
| Accessions |
EDK99399 EDK99400 EDK99401 Q8C7D2 AF229032 AAF35895 AK032836 AK050557 BAC34322 AK075959 AK076144 BAC36214 AK077707 BAC36970 AK141428 AK160219 BAE35697 BC033458 BC046967 AAH46967 BC069905 AAH69905 BC086488 AAH86488 BQ749260 CD766233 CJ073661 NM_021449 NP_067424 NM_175357 NP_780566
|
| Function |
Substrate recognition component of a DCX (DDB1-CUL4-X- box) E3 protein ligase complex that mediates the ubiquitination and subsequent proteasomal degradation of target proteins, such as MEIS2. Normal degradation of key regulatory proteins is required for normal limb outgrowth and expression of the fibroblast growth factor FGF8 (By similarity). May play a role in memory and learning by regulating the assembly and neuronal surface expression of large-conductance calcium-activated potassium channels in brain regions involved in memory and learning via its interaction with KCNT1 (By similarity). {ECO:0000250|UniProtKB:Q96SW2, ECO:0000305}.
|
| Subcellular Location |
Cytoplasm {ECO:0000250|UniProtKB:Q96SW2}. Nucleus {ECO:0000250|UniProtKB:Q96SW2}. Membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}.
|
| Tissue Specificity |
Highly expressed in brain. {ECO:0000269|PubMed:20131966}.
|