ADIPOQ
| Gene Symbol | ADIPOQ |
|---|---|
| Entrez Gene | 9370 |
| Alt Symbol | ACDC, ACRP30, ADIPQTL1, ADPN, APM-1, APM1, GBP28 |
| Species | Human |
| Gene Type | protein-coding |
| Description | adiponectin, C1Q and collagen domain containing |
| Other Description | 30 kDa adipocyte complement-related protein|adipocyte complement-related 30 kDa protein|adiponectin|adipose most abundant gene transcript 1 protein|adipose specific collagen-like factor|gelatin-binding protein 28 |
| Swissprots | Q58EX9 Q15848 |
| Accessions | BAA86716 CAB52413 CAT82843 CBL63519 EAW78165 Q15848 AK291525 BAF84214 AK312868 BAG35720 AL832470 AX767959 CAE01099 BC054496 AAH54496 BC096308 AAH96308 BC096309 AAH96309 BC096310 AAH96310 BC096311 AAH96311 D45371 BAA08227 EU420013 ABZ10942 XM_011513324 XP_011511626 NM_001177800 NP_001171271 NM_004797 NP_004788 |
| Function | Important adipokine involved in the control of fat metabolism and insulin sensitivity, with direct anti-diabetic, anti-atherogenic and anti-inflammatory activities. Stimulates AMPK phosphorylation and activation in the liver and the skeletal muscle, enhancing glucose utilization and fatty-acid combustion. Antagonizes TNF-alpha by negatively regulating its expression in various tissues such as liver and macrophages, and also by counteracting its effects. Inhibits endothelial NF-kappa-B signaling through a cAMP-dependent pathway. May play a role in cell growth, angiogenesis and tissue remodeling by binding and sequestering various growth factors with distinct binding affinities, depending on the type of complex, LMW, MMW or HMW. {ECO:0000269|PubMed:11479627}. |
| Subcellular Location | Secreted. |
| Tissue Specificity | Synthesized exclusively by adipocytes and secreted into plasma. |
| Top Pathways | Adipocytokine signaling pathway, Type II diabetes mellitus, PPAR signaling pathway, Non-alcoholic fatty liver disease (NAFLD), AMPK signaling pathway |
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