Gene Symbol | Timp3 |
---|---|
Entrez Gene | 21859 |
Alt Symbol | Timp-3 |
Species | Mouse |
Gene Type | protein-coding |
Description | tissue inhibitor of metalloproteinase 3 |
Other Description | metalloproteinase inhibitor 3|tissue inhibitor of metalloproteinases 3 |
Swissprots | P39876 Q91WL9 |
Accessions | AAA85860 EDL21437 EDL21438 P39876 AB041611 BAA95094 AK082483 AK083905 BAC39055 AK084069 AK128943 AK147847 BAE28178 AY622855 AAT46410 BC014713 AAH14713 BE651900 BY439696 L19622 AAC37669 L27424 AAA40447 Z30970 CAA83218 Z31358 NM_011595 NP_035725 |
Function | Complexes with metalloproteinases (such as collagenases) and irreversibly inactivates them by binding to their catalytic zinc cofactor. May form part of a tissue-specific acute response to remodeling stimuli. |
Subcellular Location | Secreted, extracellular space, extracellular matrix. |
Tissue Specificity | Highest levels are found in kidney, lung and brain followed by ovary and uterus. Low levels are found in bone. |
Top Pathways | MicroRNAs in cancer, Proteoglycans in cancer |