Gene Symbol | Timp3 |
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Entrez Gene | 21859 |
Alt Symbol | Timp-3 |
Species | Mouse |
Gene Type | protein-coding |
Description | tissue inhibitor of metalloproteinase 3 |
Other Description | metalloproteinase inhibitor 3|tissue inhibitor of metalloproteinases 3 |
Swissprots | P39876 Q91WL9 |
Accessions | AAA85860 EDL21437 EDL21438 P39876 AB041611 BAA95094 AK082483 AK083905 BAC39055 AK084069 AK128943 AK147847 BAE28178 AY622855 AAT46410 BC014713 AAH14713 BE651900 BY439696 L19622 AAC37669 L27424 AAA40447 Z30970 CAA83218 Z31358 NM_011595 NP_035725 |
Function | Complexes with metalloproteinases (such as collagenases) and irreversibly inactivates them by binding to their catalytic zinc cofactor. May form part of a tissue-specific acute response to remodeling stimuli. |
Subcellular Location | Secreted, extracellular space, extracellular matrix. |
Tissue Specificity | Highest levels are found in kidney, lung and brain followed by ovary and uterus. Low levels are found in bone. |
Top Pathways | MicroRNAs in cancer, Proteoglycans in cancer |
TIMP-3 CRISPR/Cas9 KO Plasmid (m) - sc-423404 from Santa Cruz Biotechnology
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TIMP-3 HDR Plasmid (m) - sc-423404-HDR from Santa Cruz Biotechnology
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TIMP-3 Double Nickase Plasmid (m) - sc-423404-NIC from Santa Cruz Biotechnology
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TIMP-3 Double Nickase Plasmid (m2) - sc-423404-NIC-2 from Santa Cruz Biotechnology
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TIMP-3 CRISPR Activation Plasmid (m) - sc-423404-ACT from Santa Cruz Biotechnology
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TIMP-3 CRISPR Activation Plasmid (m2) - sc-423404-ACT-2 from Santa Cruz Biotechnology
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TIMP-3 Lentiviral Activation Particles (m) - sc-423404-LAC from Santa Cruz Biotechnology
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TIMP-3 Lentiviral Activation Particles (m2) - sc-423404-LAC-2 from Santa Cruz Biotechnology
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TIMP-3 siRNA (m) - sc-37023 from Santa Cruz Biotechnology
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TIMP-3 shRNA Plasmid (m) - sc-37023-SH from Santa Cruz Biotechnology
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TIMP-3 shRNA (m) Lentiviral Particles - sc-37023-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EMU007051 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN42860 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND42860 from Sigma-Aldrich
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TIMP3 siRNA (Mouse) - CRM4147 from Cohesion Biosciences
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TIMP3 - MBS8231273 from MyBioSource
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shRNA set against Mouse TIMP3 (NM_011595.2) - SHH427548 from Creative biogene
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shRNA set against Mouse Timp3(NM_011595.2) - SHL071748 from Creative biogene
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Mouse TIMP3 siRNA - orb283623 from Biorbyt
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TIMP3 shRNA Plasmid (Mouse) - CHM4147 from Cohesion Biosciences
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TIMP3 miRNA 3'UTR clone - MiUTR1M-11772 from Creative biogene
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