EPHA3

Gene Symbol EPHA3
Entrez Gene 2042
Alt Symbol EK4, ETK, ETK1, HEK, HEK4, TYRO4
Species Human
Gene Type protein-coding
Description EPH receptor A3
Other Description EPH-like kinase 4|TYRO4 protein tyrosine kinase|eph-like tyrosine kinase 1|ephrin type-A receptor 3|human embryo kinase 1|tyrosine-protein kinase receptor ETK1
Swissprots Q9H2V4 P29320 Q9H2V3
Accessions CAA01906 CAM91183 CAT16931 EAW68857 P29320 AF213459 AAG43576 AF213460 AAG43577 AK024352 AK291411 BAF84100 BC026247 BC063282 AAH63282 HM437236 ADN43067 M83941 AAA58633 XM_005264715 XP_005264772 XM_005264716 XP_005264773 NM_005233 NP_005224 NM_182644 NP_872585
Function Receptor tyrosine kinase which binds promiscuously membrane-bound ephrin family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Highly promiscuous for ephrin-A ligands it binds preferentially EFNA5. Upon activation by EFNA5 regulates cell-cell adhesion, cytoskeletal organization and cell migration. Plays a role in cardiac cells migration and differentiation and regulates the formation of the atrioventricular canal and septum during development probably through activation by EFNA1. Involved in the retinotectal mapping of neurons. May also control the segregation but not the guidance of motor and sensory axons during neuromuscular circuit development. {ECO:0000269|PubMed:11870224}.
Subcellular Location Isoform 1: Cell membrane; Single-pass type I membrane protein.
Tissue Specificity Widely expressed. Highest level in placenta.
Top Pathways Axon guidance

Phospho-EphA3 (Tyr779) (D10H1) Rabbit mAb - 8862 from Cell Signaling Technology

Prices $287.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Monoclonal
Clone D10H1
Western blot analysis of extracts from SNB19 cells, serum starved overnight and either untreated (-) or treated with ephrin-A5-Fc (100 ng/ml, 5 min; +), using Phospho-EphA3 (Tyr779) (D10H1) Rabbit mAb (upper) or EphA3/A4/A5 (D2C11) Rabbit mAb #8793 (lower).

EphA3/A4/A5 (D2C11) Rabbit mAb - 8793 from Cell Signaling Technology

Prices $246.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Monoclonal
Clone D2C11
Western blot analysis of extracts from various cell lines using EphA3/A4/A5 (D2C11) Rabbit mAb.

EphA3 (D-2) - sc-514209 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
EphA3 (D-2): sc-514209. Western blot analysis of EphA3 expression in Jurkat (A), Y79 (B) and HeLa (C) whole cell lysates and human spleen tissue extract (D).

EphA3 (C-19) - sc-919 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
EphA3 (C-19): sc-919. Western blot analysis of EphA3 expression in Jurkat whole cell lysate.

EphA3 (H-80) - sc-25456 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
EphA3 (H-80): sc-25456. Western blot analysis of EphA3 expression in mouse liver tissue extract.

EphA3 (L-18) - sc-920 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
EphA3 (L-18): sc-920. Western blot analysis of EphA3 expression in JM1 (A) and Y79 (B) whole cell lysates.

EphA3 (4-RE49) - sc-134330 from Santa Cruz Biotechnology

Prices $295.00
Sizes 100 µg/ml
Host Mouse
Clonality Monoclonal
EphA3 (4-RE49): sc-134330. Western blot analysis of EphA3 expression in human EphA3 transfected (A) and non-transfected (B) 293T whole cell lysates.

Anti-EPH A3+A4+A5 (phospho Y779 + Y779 + Y833) antibody [EPR5684] - ab124881 from Abcam

Prices $379.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR5684
All lanes : Anti-EPH A3+A4+A5 (phospho Y779 + Y779 + Y833) antibody [EPR5684] (ab124881) at 1/10000 dilution (purified)Lane 1 : Untreated HEK293 cell lysateLane 2 : HEK293 cell lysate treated with pervanadateLysates/proteins at 10 µg per lane.SecondaryHRP goat anti-rabbit (H+L) at 1/1000 dilution

Anti-EPH A3+A4+A5 (phospho Y779 + Y833) antibody - ab192663 from Abcam

Prices $370.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Immunohistochemical analysis of Paraffin-embedded Human brain tissue labeling EPH A3+A4+A5 with ab192663 at 1/50 dilution. The image on the right has been pre-incubated with the blocking peptide.

Anti-EPH A3+A4+A5 (phospho Y779) antibody - ab111407 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
ab111407 at 1/50 dilution staining EPH A3+A4+A5 (phospho Y779) in paraffin-embedded Human brain tissue by Immunohistochemistry. The image on the right is treated with synthesized phosphopeptide.

Anti-Eph receptor A3 (phospho Y596) [EPR3434(N)] antibody - ab191565 from Abcam

Prices $357.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR3434(N)
All lanes : Anti-Eph receptor A3 (phospho Y596) [EPR3434(N)] antibody (ab191565) at 1/10000 dilutionLane 1 : Lysate from 293 cells treated with pervanadateLane 2 : Lysate from untreated 293 cellsLysates/proteins at 10 µg per lane.SecondaryGoat Anti-Rabbit IgG, (H+L), Peroxidase conjugated at 1/1000 dilution

Anti-Eph receptor A3 (phospho Y602) antibody - ab191498 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-Eph receptor A3 (phospho Y602) antibody (ab191498)Lane 1 : HEK293T whole cell lysateLane 2 : sp2/0 whole cell lysateLane 3 : H9C2 whole cell lysate

Anti-Eph receptor A3 antibody - ab110465 from Abcam

Prices $376.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-Eph receptor A3 antibody (ab110465) at 1/500 dilutionLane 1 : Extracts from 293 cellsLane 2 : Extracts from 293 cells, treated with the synthesized peptideLysates/proteins at 30 µg per lane.

Anti-Eph receptor A3 antibody - ab54623 from Abcam

Prices $384.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal

Anti-Eph receptor A3 antibody - ab196945 from Abcam

Prices $376.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
All lanes : Anti-Eph receptor A3 antibody (ab196945) at 1/500 dilutionLane 1 : Jurkat cell extractLane 2 : Jurkat cell extract with synthesized peptide

Anti-Eph receptor A3 antibody - ab126261 from Abcam

Prices $376.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
All lanes : Anti-Eph receptor A3 antibody (ab126261) at 1/3000 dilutionLane 1 : Juakat cell lysateLane 2 : Raji cell lysateLysates/proteins at 30 µg per lane.

Anti-Eph receptor A3 antibody [6C1B6] - ab76361 from Abcam

Host Mouse
Clonality Monoclonal
Clone 6C1B6
All lanes : Anti-Eph receptor A3 antibody [6C1B6] (ab76361) at 1/500 dilutionLane 1 : Truncated Trx-Eph receptor A3 recombinant proteinLane 2 : Truncated Eph receptor A3 (aa566-983)-hIgGFc transfected CHO-K1 cell lysate

Anti-Eph receptor A3 antibody - N-terminal - ab177910 from Abcam

Prices $376.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Anti-Eph receptor A3 antibody - N-terminal (ab177910) at 1 µg/ml + Human esophagus tumor lysate at 10 µg

Anti-Eph receptor A3 antibody - N-terminal - ab174792 from Abcam

Prices $376.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-Eph receptor A3 antibody - N-terminal (ab174792) at 1/100 dilutionLane 1 : HL-60 cell line lysateLane 2 : 293 cell line lysateLysates/proteins at 35 µg per lane.

Anti-EPHA3 / EPH Receptor A3 Antibody (clone 3A12) - LS-C197142 from LifeSpan Bioscience

Prices $355.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 3A12
EPHA3 monoclonal antibody (M01), clone 3A12. Western Blot analysis of EPHA3 expression in human spleen.

Anti-EPHA3 / EPH Receptor A3 Antibody (C-Terminus) - LS-C23121 from LifeSpan Bioscience

Prices $495.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-EPHA3 / EPH Receptor A3 Antibody (C-Terminus) - LS-C23122 from LifeSpan Bioscience

Prices $495.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal

Anti-EPHA3 / EPH Receptor A3 Antibody (Extracellular Domain) - LS-C125529 from LifeSpan Bioscience

Prices $635.00
Sizes 100 µg
Host Rat
Clonality Monoclonal

Anti-EPHA3 / EPH Receptor A3 Antibody (aa125-140) - LS-C147873 from LifeSpan Bioscience

Host Rabbit
Clonality Polyclonal

Anti-EPHA3 / EPH Receptor A3 Antibody (aa21-541) - LS-C150188 from LifeSpan Bioscience

Prices $395.00
Sizes 100 µg
Host Goat
Clonality Polyclonal
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