EPHA3

Gene Symbol	EPHA3
Entrez Gene	2042
Alt Symbol	EK4, ETK, ETK1, HEK, HEK4, TYRO4
Species	Human
Gene Type	protein-coding
Description	EPH receptor A3
Other Description	EPH-like kinase 4|TYRO4 protein tyrosine kinase|eph-like tyrosine kinase 1|ephrin type-A receptor 3|human embryo kinase 1|tyrosine-protein kinase receptor ETK1
Swissprots	Q9H2V4 P29320 Q9H2V3
Accessions	CAA01906 CAM91183 CAT16931 EAW68857 P29320 AF213459 AAG43576 AF213460 AAG43577 AK024352 AK291411 BAF84100 BC026247 BC063282 AAH63282 HM437236 ADN43067 M83941 AAA58633 XM_005264715 XP_005264772 XM_005264716 XP_005264773 NM_005233 NP_005224 NM_182644 NP_872585
Function	Receptor tyrosine kinase which binds promiscuously membrane-bound ephrin family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Highly promiscuous for ephrin-A ligands it binds preferentially EFNA5. Upon activation by EFNA5 regulates cell-cell adhesion, cytoskeletal organization and cell migration. Plays a role in cardiac cells migration and differentiation and regulates the formation of the atrioventricular canal and septum during development probably through activation by EFNA1. Involved in the retinotectal mapping of neurons. May also control the segregation but not the guidance of motor and sensory axons during neuromuscular circuit development. {ECO:0000269|PubMed:11870224}.
Subcellular Location	Isoform 1: Cell membrane; Single-pass type I membrane protein.
Tissue Specificity	Widely expressed. Highest level in placenta.
Top Pathways	Axon guidance

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

EphA3 CRISPR/Cas9 KO Plasmid (h) - sc-401565 from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

EphA3 HDR Plasmid (h) - sc-401565-HDR from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

EphA3 Double Nickase Plasmid (h) - sc-401565-NIC from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

EphA3 Double Nickase Plasmid (h2) - sc-401565-NIC-2 from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

EphA3 CRISPR Activation Plasmid (h) - sc-401565-ACT from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

EphA3 CRISPR Activation Plasmid (h2) - sc-401565-ACT-2 from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

EphA3 Lentiviral Activation Particles (h) - sc-401565-LAC from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

EphA3 Lentiviral Activation Particles (h2) - sc-401565-LAC-2 from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

EphA3 siRNA (h) - sc-39934 from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

EphA3 shRNA Plasmid (h) - sc-39934-SH from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

EphA3 shRNA (h) Lentiviral Particles - sc-39934-V from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

EphA3 RNAi - H00002042-R01V from Novus Biologicals Category siRNA Prices $399.00 Sizes 20 nmol Species Reactivities Human

EphA3 RNAi - H00002042-R07 from Novus Biologicals Category siRNA Prices $399.00 Sizes 20 nmol Species Reactivities Human

EphA3 RNAi - H00002042-R08 from Novus Biologicals Category siRNA Prices $399.00 Sizes 20 nmol Species Reactivities Human

MISSION® esiRNA - EHU002801 from Sigma-Aldrich Category siRNA

MISSION® siRNA - SIHK0687 from Sigma-Aldrich Category siRNA Prices $25.00 Sizes 0.25 nmol

MISSION® siRNA - SIHK0689 from Sigma-Aldrich Category siRNA Prices $25.00 Sizes 0.25 nmol

MISSION® siRNA - SIHK0688 from Sigma-Aldrich Category siRNA Prices $25.00 Sizes 0.25 nmol

CompoZr® Knockout ZFN Kit - CKOZFN2276 from Sigma-Aldrich Category ZFN Kit Prices $4,999.00 Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND2276 from Sigma-Aldrich Category ZFN Kit Prices $3,999.00 Sizes 1 kt

EPHA3 siRNA (Human) - CRH1419 from Cohesion Biosciences Category siRNA Prices $340.00, $510.00 Sizes 15 nmol, 30 nmol Species Reactivities Human

EPHA3 - MBS8232202 from MyBioSource Prices $365.00, $515.00 Sizes 15 nmol, 30 nmol Species Reactivities Human

shRNA set against Human EPHA3(NM_005233.5) - SHH035945 from Creative biogene Category siRNA Species Reactivities Human

shRNA set against Human EPHA3(NM_182644.2) - SHH035981 from Creative biogene Category siRNA Species Reactivities Human

Human EPHA3 siRNA - orb261921 from Biorbyt Category siRNA Prices $485.00, $629.00 Sizes 15 nmol, 30 nmol Species Reactivities Human

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