EPHA3

Gene Symbol	EPHA3
Entrez Gene	2042
Alt Symbol	EK4, ETK, ETK1, HEK, HEK4, TYRO4
Species	Human
Gene Type	protein-coding
Description	EPH receptor A3
Other Description	EPH-like kinase 4|TYRO4 protein tyrosine kinase|eph-like tyrosine kinase 1|ephrin type-A receptor 3|human embryo kinase 1|tyrosine-protein kinase receptor ETK1
Swissprots	Q9H2V4 P29320 Q9H2V3
Accessions	CAA01906 CAM91183 CAT16931 EAW68857 P29320 AF213459 AAG43576 AF213460 AAG43577 AK024352 AK291411 BAF84100 BC026247 BC063282 AAH63282 HM437236 ADN43067 M83941 AAA58633 XM_005264715 XP_005264772 XM_005264716 XP_005264773 NM_005233 NP_005224 NM_182644 NP_872585
Function	Receptor tyrosine kinase which binds promiscuously membrane-bound ephrin family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Highly promiscuous for ephrin-A ligands it binds preferentially EFNA5. Upon activation by EFNA5 regulates cell-cell adhesion, cytoskeletal organization and cell migration. Plays a role in cardiac cells migration and differentiation and regulates the formation of the atrioventricular canal and septum during development probably through activation by EFNA1. Involved in the retinotectal mapping of neurons. May also control the segregation but not the guidance of motor and sensory axons during neuromuscular circuit development. {ECO:0000269|PubMed:11870224}.
Subcellular Location	Isoform 1: Cell membrane; Single-pass type I membrane protein.
Tissue Specificity	Widely expressed. Highest level in placenta.
Top Pathways	Axon guidance

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

EPHA3 293T Cell Transient Overexpression Lysate(Denatured) - H00002042-T01 from Acris Antibodies Category Cell Lysate Prices $320.00 Sizes 100 µl

EphA3 Overexpression Lysate (Denatured) - H00002042-T01 from Novus Biologicals Category Cell Lysate Prices $279.00 Sizes 100 µl

Human EphA3 HEK293 Cell Lysate (WB positive control) - 11459-H08HL-300 from Sino Biological Category Cell Lysate Prices $195.00 Sizes 300 µg Species Human

EphA3 Overexpression Lysate (Native) - NBP2-10482 from Novus Biologicals Category Cell Lysate Prices $329.00 Sizes 100 µg

Human EPHA3 Human Cells Transfected Lysate (positive control) (denatured) - orb174453 from Biorbyt Category Cell Lysate Prices $604.00 Sizes 300 μg Species Human

Panoply™ Human EPHA3 Knockdown Stable Cell Line - CSC-DC004986 from Creative biogene Category Cell Line Species Human

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