| Gene Symbol |
Hsd11b2
|
| Entrez Gene |
25117
|
| Alt Symbol |
-
|
| Species |
Rat
|
| Gene Type |
protein-coding
|
| Description |
hydroxysteroid 11-beta dehydrogenase 2
|
| Other Description |
11-DH2|11-beta-HSD2|11-beta-hydroxysteroid dehydrogenase type 2|Hydroxysteroid dehydrogenase, 11 beta type 2|NAD-dependent 11-beta-hydroxysteroid dehydrogenase|corticosteroid 11-beta-dehydrogenase isozyme 2
|
| Swissprots |
P50233
|
| Accessions |
AAX45243 EDL92380 P50233 BC087023 AAH87023 U22424 AAA87007 XM_006255445 XP_006255507 NM_017081 NP_058777
|
| Function |
Catalyzes the conversion of cortisol to the inactive metabolite cortisone. Modulates intracellular glucocorticoid levels, thus protecting the nonselective mineralocorticoid receptor from occupation by glucocorticoids.
|
| Subcellular Location |
Microsome. Endoplasmic reticulum {ECO:0000305}.
|
| Tissue Specificity |
Highly expressed in kidney, adrenal gland and distal colon. Detected at much lower levels in lung.
|
| Top Pathways |
Steroid hormone biosynthesis, Aldosterone-regulated sodium reabsorption
|