MYD88

Gene Symbol	MYD88
Entrez Gene	4615
Alt Symbol	MYD88D
Species	Human
Gene Type	protein-coding
Description	myeloid differentiation primary response 88
Other Description	myeloid differentiation primary response gene (88)|myeloid differentiation primary response protein MyD88
Swissprots	J3KPU4 B4DKH8 Q99836 B4DKU4 Q53XS7 B4DQ72 J3KQJ6 B4DQ60 J3KQ87 P78397
Accessions	EAW64520 EAW64521 Q99836 AB446470 BAG55247 AK097983 AK124685 AK296570 BAG59190 AK296716 BAG59306 AK298650 BAG60822 AK298666 BAG60834 AK300051 BAG61860 AK300448 BAG62170 AK304676 BAG65448 AL832906 BC013589 AAH13589 BP242808 BP339466 BT007376 AAP36040 BX537602 DC350705 EU831951 ACE87392 EU832045 ACE86707 U70451 AAB49967 U84408 AAC50954 XM_005265172 XP_005265229 XM_006713170 XP_006713233 NM_001172566 NP_001166037 NM_001172567 NP_001166038 NM_001172568 NP_001166039 NM_001172569 NP_001166040 NM_002468 NP_002459
Function	Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response. Acts via IRAK1, IRAK2, IRF7 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Increases IL-8 transcription. Involved in IL-18-mediated signaling pathway. Activates IRF1 resulting in its rapid migration into the nucleus to mediate an efficient induction of IFN-beta, NOS2/INOS, and IL12A genes. MyD88-mediated signaling in intestinal epithelial cells is crucial for maintenance of gut homeostasis and controls the expression of the antimicrobial lectin REG3G in the small intestine. {ECO:0000269|PubMed:15361868, ECO:0000269|PubMed:18292575, ECO:0000269|PubMed:19506249, ECO:0000269|PubMed:9013863}.
Subcellular Location	Cytoplasm {ECO:0000269|PubMed:15361868, ECO:0000269|PubMed:15492225}.
Tissue Specificity	Ubiquitous. {ECO:0000269|PubMed:8957090}.
Top Pathways	Herpes simplex infection, Legionellosis, Tuberculosis, Pertussis, Salmonella infection

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

MyD88 Human ELISA kit - ab171341 from Abcam Category ELISA Kit Prices $489.00 Sizes 1 x 96 tests Sensitivity < 10 pg/ml Range 312 pg/ml - 20000 pg/ml

Human MYD88 ELISA Kit (Sandwich ELISA) - LS-F2777 from LifeSpan Bioscience Category ELISA Kit Prices $530.00 Sizes 1 plate Sensitivity 10 pg/ml Range 312-20000 pg/ml

Human MYD88 ELISA Kit (Sandwich ELISA) - LS-F4923 from LifeSpan Bioscience Category ELISA Kit Prices $690.00 Sizes 1 plate Sensitivity 0.055 ng/ml Range 312-20000 pg/ml

Mouse MYD88 ELISA Kit (Sandwich ELISA) - LS-F7333 from LifeSpan Bioscience Category ELISA Kit Prices $700.00 Sizes 1 plate Sensitivity 0.061 ng/ml Range 312-20000 pg/ml

Rat MYD88 ELISA Kit (Sandwich ELISA) - LS-F9240 from LifeSpan Bioscience Category ELISA Kit Prices $740.00 Sizes 1 plate Sensitivity 78.13 pg/ml Range 312-20000 pg/ml

Mouse MYD88 ELISA Kit (Sandwich ELISA) - LS-F12108 from LifeSpan Bioscience Category ELISA Kit Prices $600.00 Sizes 1 plate Sensitivity 78 Range 312-20000 pg/ml

Human MyD88 DuoSet ELISA - DY2928 from R&D Systems Category ELISA Kit Prices $649.00 Sizes 1 kit (for 15 Plates) Range 0.312 - 20 ng/mL

Human MyD88 ELISA Kit - abx152414 from Abbexa Category ELISA Kit Sensitivity 0.055 ng/ml Range 0.156 ng/ml - 10 ng/ml

Human MYD88 ELISA Kit - abx056287 from Abbexa Category ELISA Kit

Human MYD88 ELISA Kit - abx054847 from Abbexa Category ELISA Kit

Myeloid Differentiation Factor 88, MyD88, Human, ELISA Kit - E-EL-H1967 from ARP American Research Products Category ELISA Kit Prices $522.00 Sizes 96 t Sensitivity 0.094 Range 0.156-10ng/mL

MyD88, Human, ELISA Kit - PB-0942 from ARP American Research Products Category ELISA Kit Prices $418.00 Sizes 96 t Sensitivity < 10 pg/ml Range 312pg/ml-20,000pg/ml

Myeloid Differentiation Factor 88 (MyD88), Human, ELISA Kit - SEB707Hu from ARP American Research Products Category ELISA Kit Prices $685.00 Sizes 96 t Sensitivity 0.055ng/mL Range 0.156-10ng/mL

Myeloid differentiation factor 88, MyD88, Human, ELISA Kit - CSB-E11747h from ARP American Research Products Category ELISA Kit Prices $495.00, $695.00, $696.00, $699.00 Sizes 48 t, 96 t, 5 x 96t, 10 x 96t Sensitivity 0.08pg/ml Range 0.312ng/ml-20ng/ml

Myeloid differentiation primary response protein MyD88 (MYD88), Human, ELISA Kit - E01M0411 from ARP American Research Products Category ELISA Kit Prices $535.00, $735.00 Sizes 48 t, 96 t

Myeloid differentiation primary response protein MyD88, MYD88, Human, ELISA Kit - E1707h from ARP American Research Products Category ELISA Kit Prices $596.00 Sizes 96 t Range 0.156-10 ng/mL

Myeloid Differentiation Factor 88, MYD88, Rabbit, ELISA Kit - E-EL-RB0156 from ARP American Research Products Category ELISA Kit Prices $585.00 Sizes 96 t

Myeloid Differentiation Factor 88, MYD88, Chicken, ELISA Kit - E-EL-Ch1156 from ARP American Research Products Category ELISA Kit Prices $522.00 Sizes 96 t

Myeloid Differentiation Factor 88, MYD88, Porcine, ELISA Kit - E-EL-P0528 from ARP American Research Products Category ELISA Kit Prices $585.00 Sizes 96 t

Myeloid Differentiation Factor 88, MYD88, Sheep, ELISA Kit - E-EL-S0285 from ARP American Research Products Category ELISA Kit Prices $648.00 Sizes 96 t

Myeloid Differentiation Factor 88, MYD88, Guinea Pig, ELISA Kit - E-EL-GP0546 from ARP American Research Products Category ELISA Kit Prices $522.00 Sizes 96 t

Myeloid Differentiation Factor 88, MYD88, Monkey, ELISA Kit - E-EL-MK0815 from ARP American Research Products Category ELISA Kit Prices $585.00 Sizes 96 t

MYD88 (Human) IP-WB Antibody Pair - H00004615-PW2 from Acris Antibodies Category Antibody Pair Prices $610.00 Sizes 1 set

Human MyD88(Myeloid Differentiation Factor 88) ELISA Kit - E-EL-H1967 from Elabscience Category ELISA Kit Sensitivity 0.10 ng/mL Range 0.16—10 ng/mL

Human MYD88 (Myeloid Differentiation Factor 88) CLIA Kit - E-CL-H1203 from Elabscience Category CLIA Kit Sensitivity 18.75 pg/mL Range Average Recovery (%)

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