MYD88

Gene Symbol	MYD88
Entrez Gene	4615
Alt Symbol	MYD88D
Species	Human
Gene Type	protein-coding
Description	myeloid differentiation primary response 88
Other Description	myeloid differentiation primary response gene (88)|myeloid differentiation primary response protein MyD88
Swissprots	J3KPU4 B4DKH8 Q99836 B4DKU4 Q53XS7 B4DQ72 J3KQJ6 B4DQ60 J3KQ87 P78397
Accessions	EAW64520 EAW64521 Q99836 AB446470 BAG55247 AK097983 AK124685 AK296570 BAG59190 AK296716 BAG59306 AK298650 BAG60822 AK298666 BAG60834 AK300051 BAG61860 AK300448 BAG62170 AK304676 BAG65448 AL832906 BC013589 AAH13589 BP242808 BP339466 BT007376 AAP36040 BX537602 DC350705 EU831951 ACE87392 EU832045 ACE86707 U70451 AAB49967 U84408 AAC50954 XM_005265172 XP_005265229 XM_006713170 XP_006713233 NM_001172566 NP_001166037 NM_001172567 NP_001166038 NM_001172568 NP_001166039 NM_001172569 NP_001166040 NM_002468 NP_002459
Function	Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response. Acts via IRAK1, IRAK2, IRF7 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Increases IL-8 transcription. Involved in IL-18-mediated signaling pathway. Activates IRF1 resulting in its rapid migration into the nucleus to mediate an efficient induction of IFN-beta, NOS2/INOS, and IL12A genes. MyD88-mediated signaling in intestinal epithelial cells is crucial for maintenance of gut homeostasis and controls the expression of the antimicrobial lectin REG3G in the small intestine. {ECO:0000269|PubMed:15361868, ECO:0000269|PubMed:18292575, ECO:0000269|PubMed:19506249, ECO:0000269|PubMed:9013863}.
Subcellular Location	Cytoplasm {ECO:0000269|PubMed:15361868, ECO:0000269|PubMed:15492225}.
Tissue Specificity	Ubiquitous. {ECO:0000269|PubMed:8957090}.
Top Pathways	Herpes simplex infection, Legionellosis, Tuberculosis, Pertussis, Salmonella infection

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human MyD88 full length protein - ab139225 from Abcam Category Protein Source E. coli Species Human

Human MyD88 peptide - ab7882 from Abcam Category Peptide Species Human

Human MyD88 peptide - ab49768 from Abcam Category Peptide

Human MyD88 protein fragment - ab114217 from Abcam Category Protein Source Wheat germ Species Human

MyD88 peptide - ab7878 from Abcam Category Peptide

MyD88 peptide (255-265) - ab45704 from Abcam Category Peptide Species Human

MYD88 Antibody Blocking Peptide - LS-E20444 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

MYD88 Antibody Blocking Peptide - LS-E20445 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

MYD88 Antibody Blocking Peptide - LS-E25838 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

MYD88 Antibody Blocking Peptide - LS-E29895 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 50 µg

MYD88 Antibody Blocking Peptide - LS-E29894 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 50 µg

MYD88 Antibody Blocking Peptide - LS-E9617 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Recombinant Human MyD88 Protein - H00004615-P01 from Novus Biologicals Category Protein Prices $319.00 Sizes 2 µg Source Wheat Germ Species Human

MyD88 Partial Recombinant Protein - H00004615-Q01 from Novus Biologicals Category Protein Prices $369.00 Sizes 10 µg Species Human

Recombinant Human MyD88 Protein - NBP2-23255 from Novus Biologicals Category Protein Prices $269.00 Sizes 100 µg Species Human

MyD88 Blocking Peptide - NBP1-76465PEP from Novus Biologicals Category Peptide Prices $129.00 Sizes 50 µg Species Human

MyD88 Peptide - NBP1-76925PEP from Novus Biologicals Category Peptide Prices $149.00 Sizes 50 µg Species Human

MyD88-Antibody-Center-Blocking-Peptide - BP8521c from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

MyD88 blocking peptide - GTX89605-PEP from GeneTex Category Peptide Prices $239.00 Sizes 100 μg Species Human, Mouse, Dog, Rat

MyD88 peptide - GTX27878 from GeneTex Category Peptide Prices $179.00 Sizes 50 μg Species Human

MyD88 peptide - GTX27882 from GeneTex Category Peptide Prices $179.00 Sizes 50 μg Species Human

Human MYD88 protein - orb191100 from Biorbyt Category Protein Prices $170.00, $289.00 Sizes 5 μg, 20 μg Source E. coli Species Human

MYD88 Blocking Peptide - 33R-9003 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

MyD88 Blocking Peptide - 33R-10680 from Fitzgerald Category Peptide Prices $145.00 Sizes 50 µg

MYD88 Blocking Peptide - 33R-10165 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

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