| Gene Symbol | CDKN2B |
|---|---|
| Entrez Gene | 1030 |
| Alt Symbol | CDK4I, INK4B, MTS2, P15, TP15, p15INK4b |
| Species | Human |
| Gene Type | protein-coding |
| Description | cyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4) |
| Other Description | CDK inhibitory protein|CDK4B inhibitor|MTS-2|cyclin-dependent kinase 4 inhibitor B|cyclin-dependent kinases 4 and 6 binding protein|multiple tumor suppressor 2|p14-INK4b|p14_CDK inhibitor|p14_INK4B|p15 CDK inhibitor|p15-INK4b|p15_INK4B |
| Swissprots | P42772 O15125 Q6FI09 |
| Accessions | AAB32712 AAD14049 AAD14186 AAF28397 AAM44859 CAH59951 EAW58596 EAW58597 P42772 AF004819 AAB69989 AF488409 AF488410 AAO49471 AF488411 AF488731 AM392641 CAL37519 AM392962 CAL37840 AM393264 CAL38142 AM393391 CAL38269 BC014469 AAH14469 BC018984 BI560960 CR536529 CAG38766 JQ694046 AFN61601 JQ694047 AFN61602 JQ694048 AFN61603 JX391994 AGC10270 L36844 AAA50282 U17075 AAC50075 NM_004936 NP_004927 NM_078487 NP_511042 |
| Function | Interacts strongly with CDK4 and CDK6. Potent inhibitor. Potential effector of TGF-beta induced cell cycle arrest. |
| Subcellular Location | Cytoplasm {ECO:0000269|PubMed:9230210}. Note=Also found in the nucleus. |
| Tissue Specificity | Isoform 2 is expressed in normal (keratinocytes, fibroblasts) and tumor cell lines. {ECO:0000269|PubMed:9230210}. |
| Top Pathways | Cell cycle, TGF-beta signaling pathway, Small cell lung cancer, HTLV-I infection, Viral carcinogenesis |