CDKN2B

Gene Symbol CDKN2B
Entrez Gene 1030
Alt Symbol CDK4I, INK4B, MTS2, P15, TP15, p15INK4b
Species Human
Gene Type protein-coding
Description cyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4)
Other Description CDK inhibitory protein|CDK4B inhibitor|MTS-2|cyclin-dependent kinase 4 inhibitor B|cyclin-dependent kinases 4 and 6 binding protein|multiple tumor suppressor 2|p14-INK4b|p14_CDK inhibitor|p14_INK4B|p15 CDK inhibitor|p15-INK4b|p15_INK4B
Swissprots P42772 O15125 Q6FI09
Accessions AAB32712 AAD14049 AAD14186 AAF28397 AAM44859 CAH59951 EAW58596 EAW58597 P42772 AF004819 AAB69989 AF488409 AF488410 AAO49471 AF488411 AF488731 AM392641 CAL37519 AM392962 CAL37840 AM393264 CAL38142 AM393391 CAL38269 BC014469 AAH14469 BC018984 BI560960 CR536529 CAG38766 JQ694046 AFN61601 JQ694047 AFN61602 JQ694048 AFN61603 JX391994 AGC10270 L36844 AAA50282 U17075 AAC50075 NM_004936 NP_004927 NM_078487 NP_511042
Function Interacts strongly with CDK4 and CDK6. Potent inhibitor. Potential effector of TGF-beta induced cell cycle arrest.
Subcellular Location Cytoplasm {ECO:0000269|PubMed:9230210}. Note=Also found in the nucleus.
Tissue Specificity Isoform 2 is expressed in normal (keratinocytes, fibroblasts) and tumor cell lines. {ECO:0000269|PubMed:9230210}.
Top Pathways Cell cycle, TGF-beta signaling pathway, Small cell lung cancer, HTLV-I infection, Viral carcinogenesis

p15 CRISPR/Cas9 KO Plasmid (h) - sc-400570 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

p15 HDR Plasmid (h) - sc-400570-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

p15 Double Nickase Plasmid (h) - sc-400570-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

p15 Double Nickase Plasmid (h2) - sc-400570-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

p15 CRISPR Activation Plasmid (h) - sc-400570-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

p15 CRISPR Activation Plasmid (h2) - sc-400570-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

p15 Lentiviral Activation Particles (h) - sc-400570-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

p15 Lentiviral Activation Particles (h2) - sc-400570-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

p15 siRNA (h) - sc-37624 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

p15 shRNA Plasmid (h) - sc-37624-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

p15 shRNA (h) Lentiviral Particles - sc-37624-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

p15INK4b/CDKN2B RNAi - H00001030-R02 from Novus Biologicals

Category siRNA
Prices $399.00
Sizes 20 nmol
Species Reactivities Human

p15INK4b/CDKN2B RNAi - H00001030-R01 from Novus Biologicals

Category siRNA
Prices $399.00
Sizes 20 nmol
Species Reactivities Human

MISSION® esiRNA - EHU134441 from Sigma-Aldrich

Category siRNA
Prices $250.00
Sizes 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN5865 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND5865 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

MISSION® 3′UTR Lenti GoClone™ - HUTR13977 from Sigma-Aldrich

Category miRNA
Prices $350.00
Sizes hutr13977

CDKN2B siRNA (Human) - CRH0743 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

CDKN2B - MBS8206000 from MyBioSource

Prices $365.00, $515.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

p15 CRISPR/Cas9 KO Plasmid (h2) - sc-400570-KO-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

p15 HDR Plasmid (h2) - sc-400570-HDR-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

shRNA set against Human CDKN2B (NM_004936.3) - SHH260881 from Creative biogene

Category siRNA
Species Reactivities Human

shRNA set against Human CDKN2B(NM_004936.3) - SHG164413 from Creative biogene

Category siRNA
Species Reactivities Human

shRNA set against Human CDKN2B(NM_078487.2) - SHG165527 from Creative biogene

Category siRNA
Species Reactivities Human

Human CDKN2B siRNA - orb261245 from Biorbyt

Category siRNA
Prices $485.00, $629.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human
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