LPAR1

Gene Symbol LPAR1
Entrez Gene 1902
Alt Symbol EDG2, GPR26, Gpcr26, LPA1, Mrec1.3, VZG1, edg-2, rec.1.3, vzg-1
Species Human
Gene Type protein-coding
Description lysophosphatidic acid receptor 1
Other Description LPA receptor 1|LPA-1|endothelial differentiation, lysophosphatidic acid G-protein-coupled receptor, 2|lysophosphatidic acid receptor Edg-2|ventricular zone gene 1
Swissprots P78351 O00722 B4DK36 O00656 Q92633
Accessions CAC34034 CAE91525 EAW59068 EAW59069 Q92633 AK022808 BAG51118 AK290287 BAF82976 AK296374 BAG59048 AK298590 BAG60780 AK299279 BAG61296 AY322546 AAP84359 BC030615 AAH30615 BC036034 AAH36034 BC073167 AAH73167 BI461641 U78192 AAC00530 U80811 AAC51139 Y09479 CAA70686 XM_005251781 XP_005251838 XM_005251782 XP_005251839 NM_001401 NP_001392 NM_057159 NP_476500
Function Receptor for lysophosphatidic acid (LPA), a mediator of diverse cellular activities. Seems to be coupled to the G(i)/G(o), G(12)/G(13), and G(q) families of heteromeric G proteins. Stimulates phospholipase C (PLC) activity in a manner that is dependent on RALA activation. {ECO:0000269|PubMed:19306925}.
Subcellular Location Cell surface {ECO:0000269|PubMed:19306925}. Cell membrane {ECO:0000269|PubMed:19306925}; Multi-pass membrane protein {ECO:0000269|PubMed:19306925}. Note=Prior to LPA treatment found predominantly at the cell surface but in the presence of LPA colocalizes with RALA in the endocytic vesicles.
Tissue Specificity Expressed in many adult organs, including brain, heart, colon, small intestine, placenta, prostate, ovary, pancreas, testes, spleen, skeletal muscle, and kidney. Little or no expression in liver, lung, thymus, or peripheral blood leukocytes.
Top Pathways Gap junction, PI3K-Akt signaling pathway, Rap1 signaling pathway, Neuroactive ligand-receptor interaction

EDG-2 (D-15) - sc-22209 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
EDG-2 (D-15): sc-22209. Western blot analysis of EDG-2 expression in mouse brain tissue extract (A) and NIH/3T3 whole cell lysate (B).

EDG-2 (S-13) - sc-22207 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
EDG-2 (S-13): sc-22207. Western blot analysis of EDG-2 expression in A549 whole cell lysate.

Anti-EDG2 antibody - ab77940 from Abcam

Prices $384.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
ab77940 at 1/500 dilution staining EDG2 in MCF7 cells by Immunofluorescence, in the absence or presence of immunising peptide.

Anti-EDG2 antibody - ab12250 from Abcam

Prices $359.00
Sizes 25 µg
Host Rabbit
Clonality Polyclonal

Anti-EDG2 antibody - ab13027 from Abcam

Prices $359.00
Sizes 25 µg
Host Rabbit
Clonality Polyclonal

Anti-EDG2 antibody [1G6] - ab119245 from Abcam

Prices $384.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 1G6
IHC image of EDG2 staining in Human normal liver formalin fixed paraffin embedded tissue section, performed on a Leica Bond™ system using the standard protocol F. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH6, epitope retrieval solution 1) for 20 mins. The section was then incubated with ab119245, 5µg/ml, for 15 mins at room temperature and detected using an HRP conjugated compact polymer system. DAB was used as the chromogen. The section was then counterstained with haematoxylin and mounted with DPX. For other IHC staining systems (automated and non-automated) customers should optimize variable parameters such as antigen retrieval conditions, primary antibody concentration and antibody incubation times.

Anti-EDG2 antibody [EPR9710] - ab166903 from Abcam

Prices $385.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR9710
All lanes : Anti-EDG2 antibody [EPR9710] (ab166903) at 1/1000 dilutionLane 1 : Jurkat cell lysateLane 2 : HeLa cell lysateLane 3 : Caco 2 cell lysateLane 4 : A375 cell lysateLysates/proteins at 10 µg per lane.Secondarygoat anti-rabbit HRP IgG antibody at 1/2000 dilution

Anti-LPAR1 / LPA1 / EDG2 Antibody (aa328-344) - LS-C22993 from LifeSpan Bioscience

Prices $475.00
Sizes 200 µg
Host Rabbit
Clonality Polyclonal

Anti-LPAR1 / LPA1 / EDG2 Antibody (aa36-51) - LS-C3009 from LifeSpan Bioscience

Prices $285.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-LPAR1 / LPA1 / EDG2 Antibody - LS-C96205 from LifeSpan Bioscience

Prices $345.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-LPAR1 / LPA1 / EDG2 Antibody (clone 2E2) - LS-C197102 from LifeSpan Bioscience

Prices $355.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 2E2

Anti-LPAR1 / LPA1 / EDG2 Antibody (aa28-58, AP) - LS-C256487 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-LPAR1 / LPA1 / EDG2 Antibody (aa200-300) - LS-C83870 from LifeSpan Bioscience

Prices $335.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Detection of EDG2 in A549 whole cell extracts.

Anti-LPAR1 / LPA1 / EDG2 Antibody (aa28-58, APC) - LS-C256488 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-LPAR1 / LPA1 / EDG2 Antibody (aa28-58, Biotin) - LS-C256489 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-LPAR1 / LPA1 / EDG2 Antibody (aa28-58, Azide-free, HRP) - LS-C256491 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-LPAR1 / LPA1 / EDG2 Antibody (aa28-58, PE) - LS-C256493 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-LPAR1 / LPA1 / EDG2 Antibody (aa28-58, FITC) - LS-C256490 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-LPAR1 / LPA1 / EDG2 Antibody (aa28-58) - LS-C329488 from LifeSpan Bioscience

Prices $345.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-LPAR1 / LPA1 / EDG2 Antibody (aa342-359) - LS-C137367 from LifeSpan Bioscience

Prices $265.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-LPAR1 / LPA1 / EDG2 Antibody (aa21-50) - LS-C100386 from LifeSpan Bioscience

Prices $295.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
The anti-EDG2 N-term Antibody is used in Western blot to detect EDG2 in A375 lysate.

Anti-LPAR1 / LPA1 / EDG2 Antibody (Trp45) IHC-plus™ - LS-B10423 from LifeSpan Bioscience

Prices $395.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Anti-LPAR1 / LPA1 / EDG2 antibody IHC staining of human small intestine. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B10423 concentration 5 ug/ml.

Anti-LPAR1 / LPA1 / EDG2 Antibody (aa5-54) IHC-plus™ - LS-B5690 from LifeSpan Bioscience

Prices $395.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Anti-EDG2 antibody IHC of human brain, cerebellum. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B5690 concentration 10 ug/ml.

Anti-LPAR1 / LPA1 / EDG2 Antibody (clone 1G6) - LS-C173399 from LifeSpan Bioscience

Prices $350.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 1G6
Anti-LPAR1 mouse monoclonal antibody immunofluorescent staining of COS7 cells transiently transfected by pCMV6-ENTRY LPAR1.

Anti-LPAR1 / LPA1 / EDG2 Antibody (aa342-359) IHC-plus™ - LS-B1498 from LifeSpan Bioscience

Prices $395.00
Sizes 1 ea
Host Rabbit
Clonality Polyclonal
Anti-EDG2 antibody IHC of human kidney. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B1498 concentration 10 ug/ml.
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