EP300

Gene Symbol	EP300
Entrez Gene	2033
Alt Symbol	KAT3B, RSTS2, p300
Species	Human
Gene Type	protein-coding
Description	E1A binding protein p300
Other Description	E1A-associated protein p300|E1A-binding protein, 300kD|histone acetyltransferase p300|p300 HAT
Swissprots	Q09472 B1AKC2
Accessions	ABB16440 CAM82745 EAW60408 Q09472 AA235167 AB385004 BAG10860 AI302618 BC053889 AAH53889 BC172280 AAI72280 BQ428177 BQ921059 BQ930911 CA393789 CB132795 CB155618 CF130065 CN278277 CN278282 D53020 DB047746 N57495 U01877 AAA18639 XM_006724165 XP_006724228 NM_001429 NP_001420
Function	Functions as histone acetyltransferase and regulates transcription via chromatin remodeling. Acetylates all four core histones in nucleosomes. Histone acetylation gives an epigenetic tag for transcriptional activation. Mediates cAMP-gene regulation by binding specifically to phosphorylated CREB protein. Mediates acetylation of histone H3 at 'Lys-122' (H3K122ac), a modification that localizes at the surface of the histone octamer and stimulates transcription, possibly by promoting nucleosome instability. Mediates acetylation of histone H3 at 'Lys-27' (H3K27ac). Also functions as acetyltransferase for nonhistone targets. Acetylates 'Lys-131' of ALX1 and acts as its coactivator in the presence of CREBBP. Acetylates SIRT2 and is proposed to indirectly increase the transcriptional activity of TP53 through acetylation and subsequent attenuation of SIRT2 deacetylase function. Acetylates HDAC1 leading to its inactivation and modulation of transcription. Acts as a TFAP2A-mediated transcriptiona
Subcellular Location	Cytoplasm. Nucleus. Note=In the presence of ALX1 relocalizes from the cytoplasm to the nucleus. Colocalizes with ROCK2 in the nucleus.
Top Pathways	Viral carcinogenesis, Glucagon signaling pathway, Epstein-Barr virus infection, MicroRNAs in cancer, cAMP signaling pathway

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

SimpleChIP ® Human EP300 Promoter Primers - 12281 from Cell Signaling Technology Category ChIP Kit Prices $102.00 Sizes 500 µl (250 PCR reactions)

KAT3B/p300 Inhibitor Screening Assay Kit (Fluorometric) - ab196996 from Abcam Category Cellular Assay Prices $525.00 Sizes 100 tests

Human EP300 / p300 ELISA Kit (Sandwich ELISA) - LS-F6932 from LifeSpan Bioscience Category ELISA Kit Prices $720.00 Sizes 1 plate Sensitivity 0.056 ng/ml Range 0.156-10 ng/ml

Mouse/Human/Rat EP300 / p300 ELISA Kit (Cell-Based ELISA) - LS-F2204 from LifeSpan Bioscience Category ELISA Kit Prices $450.00 Sizes 1 plate Range 0.156-10 ng/ml

Mouse EP300 / p300 ELISA Kit (Sandwich ELISA) - LS-F8696 from LifeSpan Bioscience Category ELISA Kit Prices $740.00 Sizes 1 plate Sensitivity 0.055 ng/ml Range 0.156-10 ng/ml

Rat EP300 / p300 ELISA Kit (Sandwich ELISA) - LS-F8697 from LifeSpan Bioscience Category ELISA Kit Prices $780.00 Sizes 1 plate Sensitivity 0.118 ng/ml Range 0.156-10 ng/ml

Rabbit anti-p300 Antibody, Affinity Purified - PLA0096 from Sigma-Aldrich Prices $323.50 Sizes 100 µl

Human EP300 ELISA Kit - abx151421 from Abbexa Category ELISA Kit Sensitivity 0.055 ng/ml Range 0.156 ng/ml - 10 ng/ml

E1A Binding Protein P300 (EP300), Human, ELISA Kit - SEC216Hu from ARP American Research Products Category ELISA Kit Prices $720.00 Sizes 96 t Sensitivity 0.071ng/mL Range 0.156-10ng/mL

p300 Colorimetric Cell-Based ELISA Kit - CB5512 from Assay Biotechnology Category ELISA Kit Prices $380.00, $760.00, $1,140.00 Sizes 1 kit, 2 kits, 3 kits Range > 5000 Cells

E1A binding protein p300, ELISA Kit - MBS9321212 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

E1A Binding Protein P300 (EP300), ELISA Kit - MBS2020903 from MyBioSource Category ELISA Kit Prices $385.00, $575.00, $785.00, $3,210.00, $5,825.00 Sizes 24 -strip-wells, 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity Typically less than 0.055ng/mL. Range 0.156-10ng/mL

E1A Binding Protein P300 (EP300), ELISA Kit - MBS2022980 from MyBioSource Category ELISA Kit Prices $380.00, $565.00, $765.00, $3,130.00, $5,670.00 Sizes 24 -strip-wells, 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity Typically less than 0.055ng/mL. Range 0.156-10ng/mL

E1A Binding Protein P300 (EP300), ELISA Kit - MBS2021772 from MyBioSource Category ELISA Kit Prices $405.00, $605.00, $820.00, $3,375.00, $6,125.00 Sizes 24 -strip-wells, 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity Typically less than 0.118ng/mL. Range 0.313-20ng/mL

ELISA Kit for E1A Binding Protein P300 (EP300) - SEC216Hu from Uscn Life Science Inc. Category ELISA Kit Sensitivity The minimum detectable dose of this kit is typically less than 0.055ng/mL. Range 0.156-10ng/mL The standard curve concentrations used for the ELISA’s were 10ng/mL, 5ng/mL, 2.5ng/mL, 1.25ng/mL, 0.625ng/mL, 0.313ng/mL, 0.156ng/mL

ELISA Kit for E1A Binding Protein P300 (EP300) - SEC216Mu from Uscn Life Science Inc. Category ELISA Kit Sensitivity The minimum detectable dose of this kit is typically less than 0.055ng/mL. Range 0.156-10ng/mL The standard curve concentrations used for the ELISA’s were 10ng/mL, 5ng/mL, 2.5ng/mL, 1.25ng/mL, 0.625ng/mL, 0.313ng/mL, 0.156ng/mL

ELISA Kit for E1A Binding Protein P300 (EP300) - SEC216Ra from Uscn Life Science Inc. Category ELISA Kit Sensitivity The minimum detectable dose of this kit is typically less than 0.118ng/mL. Range 0.313-20ng/mL The standard curve concentrations used for the ELISA’s were 20ng/mL, 10ng/mL, 5ng/mL, 2.5ng/mL, 1.25ng/mL, 0.625ng/mL, 0.313ng/mL

ELISA Kit for E1A Binding Protein P300 (EP300) - SEC216Hu from Cloud-clone Category ELISA Kit Sensitivity The minimum detectable dose of this kit is typically less than 0.055ng/mL. Range 0.156-10ng/mL The standard curve concentrations used for the ELISA's were 10ng/mL, 5ng/mL, 2.5ng/mL, 1.25ng/mL, 0.625ng/mL, 0.313ng/mL, 0.156ng/mL

E1A Binding Protein P300 (EP300), Human, ELISA Kit - DL-EP300-Hu from ARP American Research Products Category ELISA Kit Prices $655.00 Sizes 96 t Range 0.156-10 ng/mL

p300 ELISA Kit - DEIA-XYA1366 from Creative Diagnostics Category ELISA Kit

p300/CBP ELISA Kit - DEIA-XYA1367 from Creative Diagnostics Category ELISA Kit

Human EP300 ELISA Kit - abx570858 from Abbexa Category ELISA Kit Sensitivity 0.071 ng/ml Range 0.156 ng/ml - 10 ng/ml

Human EP300 ELISA Kit - E012615 from Biobool Category ELISA Kit Sensitivity Typically less than 0.055ng/mL.

EP300 ELISA Kit (Human) (OKCD01654) - OKCD01654 from Aviva Systems Biology Category ELISA Kit Prices $545.00 Sizes 96 wells Sensitivity < 0.056 ng/mL Range 0.156 - 10 ng/mL

anti-p300 / CBP antibody - ARG52903 from Arigo Biolaboratories Category ELISA Kit

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