EP300

Gene Symbol	EP300
Entrez Gene	2033
Alt Symbol	KAT3B, RSTS2, p300
Species	Human
Gene Type	protein-coding
Description	E1A binding protein p300
Other Description	E1A-associated protein p300|E1A-binding protein, 300kD|histone acetyltransferase p300|p300 HAT
Swissprots	Q09472 B1AKC2
Accessions	ABB16440 CAM82745 EAW60408 Q09472 AA235167 AB385004 BAG10860 AI302618 BC053889 AAH53889 BC172280 AAI72280 BQ428177 BQ921059 BQ930911 CA393789 CB132795 CB155618 CF130065 CN278277 CN278282 D53020 DB047746 N57495 U01877 AAA18639 XM_006724165 XP_006724228 NM_001429 NP_001420
Function	Functions as histone acetyltransferase and regulates transcription via chromatin remodeling. Acetylates all four core histones in nucleosomes. Histone acetylation gives an epigenetic tag for transcriptional activation. Mediates cAMP-gene regulation by binding specifically to phosphorylated CREB protein. Mediates acetylation of histone H3 at 'Lys-122' (H3K122ac), a modification that localizes at the surface of the histone octamer and stimulates transcription, possibly by promoting nucleosome instability. Mediates acetylation of histone H3 at 'Lys-27' (H3K27ac). Also functions as acetyltransferase for nonhistone targets. Acetylates 'Lys-131' of ALX1 and acts as its coactivator in the presence of CREBBP. Acetylates SIRT2 and is proposed to indirectly increase the transcriptional activity of TP53 through acetylation and subsequent attenuation of SIRT2 deacetylase function. Acetylates HDAC1 leading to its inactivation and modulation of transcription. Acts as a TFAP2A-mediated transcriptiona
Subcellular Location	Cytoplasm. Nucleus. Note=In the presence of ALX1 relocalizes from the cytoplasm to the nucleus. Colocalizes with ROCK2 in the nucleus.
Top Pathways	Viral carcinogenesis, Glucagon signaling pathway, Epstein-Barr virus infection, MicroRNAs in cancer, cAMP signaling pathway

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human KAT3B / p300 full length protein - ab82235 from Abcam Category Protein Source Baculovirus Species Human

Human KAT3B / p300 protein fragment - ab105913 from Abcam Category Protein Source Baculovirus infected sf9 cells Species Human

Human KAT3B / p300 protein fragment - ab198116 from Abcam Category Protein Source E. coli Species Human

Human KAT3B / p300 protein fragment - ab56274 from Abcam Category Protein Source Baculovirus infected sf9 cells Species Human

Human KAT3B / p300 protein fragment - ab82076 from Abcam Category Protein Source E. coli Species Human

Human KAT3B / p300 protein fragment - ab82234 from Abcam Category Protein Source Baculovirus Species Human

KAT3B / p300 peptide - ab4914 from Abcam Category Peptide

EP300 / p300 Antibody Blocking Peptide - LS-E7300 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Recombinant Human KAT3B/p300 Protein - H00002033-Q01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

KAT3B/p300 Peptide - P1377 from Novus Biologicals Category Peptide Species Human

Phospho-EP300S89-Antibody-Blocking-peptide - BP3197a from Abgent, a WuXi AppTec company Category Peptide Prices $120.00 Sizes 100 µg

Biotinylated-P300-S89-Non-phospho-Control-Peptide - SP2042d from Abgent, a WuXi AppTec company Category Peptide Prices $150.00 Sizes 1 mg

P300-S89-Non-phospho-Control-Peptide - SP2042c from Abgent, a WuXi AppTec company Category Peptide Prices $132.00 Sizes 1 mg

Biotinylated-P300-S89-Phospho-Peptide - SP2042b from Abgent, a WuXi AppTec company Category Peptide Prices $300.00 Sizes 1 mg

P300-S89-Phospho-Peptide - SP2042a from Abgent, a WuXi AppTec company Category Peptide Prices $150.00 Sizes 1 mg

EP300 peptide - orb218819 from Biorbyt Category Peptide Prices $357.00, $723.00 Sizes 1 mg, 5 mg Species Human, Mouse, Rat

HAT protein - 30R-2412 from Fitzgerald Category Protein Prices $335.00 Sizes 100 µg Source E.coli Species Human

p300 (phospho-Ser1834) Blocking Peptide - abx064150 from Abbexa Category Peptide Species Human, Mouse, Rat

p300 Blocking Peptide - abx062583 from Abbexa Category Peptide Species Human, Mouse, Rat, Bovine, Chicken, Dog, Pig

EP300 / P300 - H00002033-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

EP300 / P300 - H00002033-Q01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

EP300 / P300 Control Peptide - SP5316CP from Acris Antibodies Category Peptide Prices $205.00 Sizes 50 µg

Recombinant p300 (1041-1161) protein - 31372 from ActiveMotif Category Protein Prices $395.00, $2,600.00 Sizes 100 µg, 1 mg Source E. coli Species Human

Recombinant p300 protein - 31124 from ActiveMotif Category Protein Prices $495.00 Sizes 4 µg Source Baculovirus Species Human

Recombinant p300 protein, catalytic domain - 31205 from ActiveMotif Category Protein Prices $390.00 Sizes 5 µg Source Baculovirus Species Human

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