EP300

Gene Symbol EP300
Entrez Gene 2033
Alt Symbol KAT3B, RSTS2, p300
Species Human
Gene Type protein-coding
Description E1A binding protein p300
Other Description E1A-associated protein p300|E1A-binding protein, 300kD|histone acetyltransferase p300|p300 HAT
Swissprots Q09472 B1AKC2
Accessions ABB16440 CAM82745 EAW60408 Q09472 AA235167 AB385004 BAG10860 AI302618 BC053889 AAH53889 BC172280 AAI72280 BQ428177 BQ921059 BQ930911 CA393789 CB132795 CB155618 CF130065 CN278277 CN278282 D53020 DB047746 N57495 U01877 AAA18639 XM_006724165 XP_006724228 NM_001429 NP_001420
Function Functions as histone acetyltransferase and regulates transcription via chromatin remodeling. Acetylates all four core histones in nucleosomes. Histone acetylation gives an epigenetic tag for transcriptional activation. Mediates cAMP-gene regulation by binding specifically to phosphorylated CREB protein. Mediates acetylation of histone H3 at 'Lys-122' (H3K122ac), a modification that localizes at the surface of the histone octamer and stimulates transcription, possibly by promoting nucleosome instability. Mediates acetylation of histone H3 at 'Lys-27' (H3K27ac). Also functions as acetyltransferase for nonhistone targets. Acetylates 'Lys-131' of ALX1 and acts as its coactivator in the presence of CREBBP. Acetylates SIRT2 and is proposed to indirectly increase the transcriptional activity of TP53 through acetylation and subsequent attenuation of SIRT2 deacetylase function. Acetylates HDAC1 leading to its inactivation and modulation of transcription. Acts as a TFAP2A-mediated transcriptiona
Subcellular Location Cytoplasm. Nucleus. Note=In the presence of ALX1 relocalizes from the cytoplasm to the nucleus. Colocalizes with ROCK2 in the nucleus.
Top Pathways Viral carcinogenesis, Glucagon signaling pathway, Epstein-Barr virus infection, MicroRNAs in cancer, cAMP signaling pathway

p300 CRISPR/Cas9 KO Plasmid (h) - sc-400055 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

p300 HDR Plasmid (h) - sc-400055-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

p300 Double Nickase Plasmid (h) - sc-400055-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

p300 Double Nickase Plasmid (h2) - sc-400055-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

p300 CRISPR Activation Plasmid (h) - sc-400055-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

p300 CRISPR Activation Plasmid (h2) - sc-400055-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

p300 Lentiviral Activation Particles (h) - sc-400055-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

p300 Lentiviral Activation Particles (h2) - sc-400055-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

p300 siRNA (h) - sc-29431 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

p300 shRNA Plasmid (h) - sc-29431-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

p300 shRNA (h) Lentiviral Particles - sc-29431-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

KAT3B/p300 RNAi - H00002033-R01 from Novus Biologicals

Category siRNA
Prices $399.00
Sizes 20 nmol
Species Reactivities Human

MISSION® esiRNA - EHU155151 from Sigma-Aldrich

Category siRNA
Prices $250.00
Sizes 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN1986 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND1986 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

EP300 siRNA (Human) - CRH1410 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

EP300 - MBS8208327 from MyBioSource

Prices $365.00, $515.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

shRNA set against Human EP300 (NM_001429.3) - SHH286141 from Creative biogene

Category siRNA
Species Reactivities Human

Human EP300 siRNA - orb261912 from Biorbyt

Category siRNA
Prices $485.00, $629.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

EP300 shRNA Plasmid (Human) - CHH1410 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human

EP300 miRNA 3'UTR clone - MiUTR3H-05241 from Creative biogene

Species Reactivities Human
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