| Gene Symbol |
Tfpi
|
| Entrez Gene |
21788
|
| Alt Symbol |
A630013F22Rik, AW552122, EPI, LACI
|
| Species |
Mouse
|
| Gene Type |
protein-coding
|
| Description |
tissue factor pathway inhibitor
|
| Other Description |
extrinsic pathway inhibitor|lipoprotein-associated coagulation inhibitor
|
| Swissprots |
Q9Z2U8 O54819
|
| Accessions |
EDL27281 EDL27282 EDL27283 EDL27284 O54819 AF004833 AAC40035 AF016313 AAD01586 AK028356 BAC25901 AK034752 BAC28821 AK041472 AK084706 AK164207 AK167522 BC036146 AAH36146 BY307762 XM_006499145 XP_006499208 XM_006499146 XP_006499209 XM_006499147 XP_006499210 XM_006499148 XP_006499211 XM_006499149 XP_006499212 XM_006499150 XP_006499213 NM_001177319 NP_001170790 NM_001177320 NP_001170791 NM_011576 NP_035706
|
| Function |
Inhibits factor X (X(a)) directly and, in a Xa-dependent way, inhibits VIIa/tissue factor activity, presumably by forming a quaternary Xa/LACI/VIIa/TF complex. It possesses an antithrombotic action and also the ability to associate with lipoproteins in plasma (By similarity). {ECO:0000250}.
|
| Subcellular Location |
Secreted.
|
| Tissue Specificity |
Isoform alpha is expressed in heart and spleen; isoform beta in heart and lung.
|
| Top Pathways |
Complement and coagulation cascades
|