Gene Symbol | Tfpi |
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Entrez Gene | 21788 |
Alt Symbol | A630013F22Rik, AW552122, EPI, LACI |
Species | Mouse |
Gene Type | protein-coding |
Description | tissue factor pathway inhibitor |
Other Description | extrinsic pathway inhibitor|lipoprotein-associated coagulation inhibitor |
Swissprots | Q9Z2U8 O54819 |
Accessions | EDL27281 EDL27282 EDL27283 EDL27284 O54819 AF004833 AAC40035 AF016313 AAD01586 AK028356 BAC25901 AK034752 BAC28821 AK041472 AK084706 AK164207 AK167522 BC036146 AAH36146 BY307762 XM_006499145 XP_006499208 XM_006499146 XP_006499209 XM_006499147 XP_006499210 XM_006499148 XP_006499211 XM_006499149 XP_006499212 XM_006499150 XP_006499213 NM_001177319 NP_001170790 NM_001177320 NP_001170791 NM_011576 NP_035706 |
Function | Inhibits factor X (X(a)) directly and, in a Xa-dependent way, inhibits VIIa/tissue factor activity, presumably by forming a quaternary Xa/LACI/VIIa/TF complex. It possesses an antithrombotic action and also the ability to associate with lipoproteins in plasma (By similarity). {ECO:0000250}. |
Subcellular Location | Secreted. |
Tissue Specificity | Isoform alpha is expressed in heart and spleen; isoform beta in heart and lung. |
Top Pathways | Complement and coagulation cascades |
TFPI CRISPR/Cas9 KO Plasmid (m) - sc-423361 from Santa Cruz Biotechnology
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TFPI HDR Plasmid (m) - sc-423361-HDR from Santa Cruz Biotechnology
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TFPI Double Nickase Plasmid (m) - sc-423361-NIC from Santa Cruz Biotechnology
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TFPI Double Nickase Plasmid (m2) - sc-423361-NIC-2 from Santa Cruz Biotechnology
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TFPI CRISPR Activation Plasmid (m) - sc-423361-ACT from Santa Cruz Biotechnology
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TFPI CRISPR Activation Plasmid (m2) - sc-423361-ACT-2 from Santa Cruz Biotechnology
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TFPI Lentiviral Activation Particles (m) - sc-423361-LAC from Santa Cruz Biotechnology
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TFPI Lentiviral Activation Particles (m2) - sc-423361-LAC-2 from Santa Cruz Biotechnology
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TFPI siRNA (m) - sc-41061 from Santa Cruz Biotechnology
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TFPI shRNA Plasmid (m) - sc-41061-SH from Santa Cruz Biotechnology
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TFPI shRNA (m) Lentiviral Particles - sc-41061-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EMU056111 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN42752 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND42752 from Sigma-Aldrich
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TFPI siRNA (Mouse) - CRM4108 from Cohesion Biosciences
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TFPI - MBS8234787 from MyBioSource
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shRNA set against Mouse TFPI (NM_011576.1) - SHH426280 from Creative biogene
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shRNA set against Mouse Tfpi(NM_011576.1) - SHH222956 from Creative biogene
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TFPI shRNA Plasmid (Mouse) - CHM4108 from Cohesion Biosciences
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TFPI miRNA 3'UTR clone - MiUTR1M-11701 from Creative biogene
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