| Gene Symbol |
Nr1h4
|
| Entrez Gene |
60351
|
| Alt Symbol |
Fxr
|
| Species |
Rat
|
| Gene Type |
protein-coding
|
| Description |
nuclear receptor subfamily 1, group H, member 4
|
| Other Description |
RXR-interacting protein 14|bile acid receptor|farnesoid X activated receptor|farnesoid X-activated receptor|farnesol receptor HRR-1|retinoid X receptor-interacting protein 14
|
| Swissprots |
Q62735
|
| Accessions |
EDM16985 EDM16986 Q62735 BC083815 AAH83815 U18374 AAC52205 XM_008765260 XP_008763482 XM_008765261 XP_008763483 XM_008765262 XP_008763484 NM_021745 NP_068513
|
| Function |
Ligand-activated transcription factor. Receptor for bile acids such as chenodeoxycholic acid, lithocholic acid and deoxycholic acid. Represses the transcription of the cholesterol 7-alpha-hydroxylase gene (CYP7A1) and activates the intestinal bile acid-binding protein (IBABP). Activates the transcription of bile salt export pump ABCB11 by directly recruiting histone methyltransferase CARM1 within its gene locus (By similarity). {ECO:0000250}.
|
| Subcellular Location |
Nucleus {ECO:0000305}.
|
| Top Pathways |
Bile secretion
|