| Gene Symbol | Nr1h4 |
|---|---|
| Entrez Gene | 60351 |
| Alt Symbol | Fxr |
| Species | Rat |
| Gene Type | protein-coding |
| Description | nuclear receptor subfamily 1, group H, member 4 |
| Other Description | RXR-interacting protein 14|bile acid receptor|farnesoid X activated receptor|farnesoid X-activated receptor|farnesol receptor HRR-1|retinoid X receptor-interacting protein 14 |
| Swissprots | Q62735 |
| Accessions | EDM16985 EDM16986 Q62735 BC083815 AAH83815 U18374 AAC52205 XM_008765260 XP_008763482 XM_008765261 XP_008763483 XM_008765262 XP_008763484 NM_021745 NP_068513 |
| Function | Ligand-activated transcription factor. Receptor for bile acids such as chenodeoxycholic acid, lithocholic acid and deoxycholic acid. Represses the transcription of the cholesterol 7-alpha-hydroxylase gene (CYP7A1) and activates the intestinal bile acid-binding protein (IBABP). Activates the transcription of bile salt export pump ABCB11 by directly recruiting histone methyltransferase CARM1 within its gene locus (By similarity). {ECO:0000250}. |
| Subcellular Location | Nucleus {ECO:0000305}. |
| Top Pathways | Bile secretion |
FXR siRNA (r) - sc-108079 from Santa Cruz Biotechnology
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FXR shRNA Plasmid (r) - sc-108079-SH from Santa Cruz Biotechnology
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CompoZr® Knockout ZFN Kit - CKOZFN58136 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND58136 from Sigma-Aldrich
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NR1H4 siRNA (Rat) - CRR1675 from Cohesion Biosciences
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shRNA set against Rat NR1H4 (NM_021745.1) - SHH354692 from Creative biogene
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shRNA set against Rat Nr1h4(NM_021745.1) - SHR019937 from Creative biogene
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NR1H4 shRNA Plasmid (Rat) - CHR1675 from Cohesion Biosciences
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NR1H4 miRNA 3'UTR clone - MiUTR1R-04273 from Creative biogene
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