Gene Symbol | Nr1h4 |
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Entrez Gene | 60351 |
Alt Symbol | Fxr |
Species | Rat |
Gene Type | protein-coding |
Description | nuclear receptor subfamily 1, group H, member 4 |
Other Description | RXR-interacting protein 14|bile acid receptor|farnesoid X activated receptor|farnesoid X-activated receptor|farnesol receptor HRR-1|retinoid X receptor-interacting protein 14 |
Swissprots | Q62735 |
Accessions | EDM16985 EDM16986 Q62735 BC083815 AAH83815 U18374 AAC52205 XM_008765260 XP_008763482 XM_008765261 XP_008763483 XM_008765262 XP_008763484 NM_021745 NP_068513 |
Function | Ligand-activated transcription factor. Receptor for bile acids such as chenodeoxycholic acid, lithocholic acid and deoxycholic acid. Represses the transcription of the cholesterol 7-alpha-hydroxylase gene (CYP7A1) and activates the intestinal bile acid-binding protein (IBABP). Activates the transcription of bile salt export pump ABCB11 by directly recruiting histone methyltransferase CARM1 within its gene locus (By similarity). {ECO:0000250}. |
Subcellular Location | Nucleus {ECO:0000305}. |
Top Pathways | Bile secretion |
Recombinant Rat Nr1h4, His-tagged - Nr1h4-07R from Creative Biomart
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Recombinant Farnesoid X Receptor (FXR) - RPC042Ra01 from Cloud-clone
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Recombinant Rat Bile acid receptor(Nr1h4) - CSB-YP733839RA CSB-EP733839RA CSB-BP733839RA CSB-MP733839RA from Cusabio
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Recombinant Rat NR1H4 Protein - NR1H4-4064R from Creative Biomart
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Bile acid receptor (Nr1h4), Recombinant Protein - MBS1386429 from MyBioSource
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