| Gene Symbol |
Nfe2l2
|
| Entrez Gene |
18024
|
| Alt Symbol |
AI194320, Nrf2
|
| Species |
Mouse
|
| Gene Type |
protein-coding
|
| Description |
nuclear factor, erythroid derived 2, like 2
|
| Other Description |
NF-E2-related factor 2|NFE2-related factor 2|nuclear factor erythroid 2-related factor 2
|
| Swissprots |
Q60795 Q3UQK0
|
| Accessions |
AAC52983 EDL27192 EDL27193 EDL27194 Q60795 AK029360 AK142347 BAE25040 AK144247 BC003340 AAH03340 BC026943 AAH26943 BC057948 BY792550 U20532 AAA68291 NM_010902 NP_035032
|
| Function |
Transcription activator that binds to antioxidant response (ARE) elements in the promoter regions of target genes. Important for the coordinated up-regulation of genes in response to oxidative stress. May be involved in the transcriptional activation of genes of the beta-globin cluster by mediating enhancer activity of hypersensitive site 2 of the beta-globin locus control region. {ECO:0000269|PubMed:9887101}.
|
| Subcellular Location |
Cytoplasm, cytosol {ECO:0000269|PubMed:9887101}. Nucleus {ECO:0000255|PROSITE- ProRule:PRU00978, ECO:0000269|PubMed:9887101}. Note=Cytosolic under unstressed conditions, translocates into the nucleus upon induction by electrophilic agents.
|
| Tissue Specificity |
Widely expressed. Highest expression in liver, skeletal muscle, luminal cells of the stomach and intestine, lining of the bronchi and alveoli, and in renal tubules; followed by heart, spleen, testis and brain.
|
| Top Pathways |
Protein processing in endoplasmic reticulum
|