Gene Symbol | Nfe2l2 |
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Entrez Gene | 18024 |
Alt Symbol | AI194320, Nrf2 |
Species | Mouse |
Gene Type | protein-coding |
Description | nuclear factor, erythroid derived 2, like 2 |
Other Description | NF-E2-related factor 2|NFE2-related factor 2|nuclear factor erythroid 2-related factor 2 |
Swissprots | Q60795 Q3UQK0 |
Accessions | AAC52983 EDL27192 EDL27193 EDL27194 Q60795 AK029360 AK142347 BAE25040 AK144247 BC003340 AAH03340 BC026943 AAH26943 BC057948 BY792550 U20532 AAA68291 NM_010902 NP_035032 |
Function | Transcription activator that binds to antioxidant response (ARE) elements in the promoter regions of target genes. Important for the coordinated up-regulation of genes in response to oxidative stress. May be involved in the transcriptional activation of genes of the beta-globin cluster by mediating enhancer activity of hypersensitive site 2 of the beta-globin locus control region. {ECO:0000269|PubMed:9887101}. |
Subcellular Location | Cytoplasm, cytosol {ECO:0000269|PubMed:9887101}. Nucleus {ECO:0000255|PROSITE- ProRule:PRU00978, ECO:0000269|PubMed:9887101}. Note=Cytosolic under unstressed conditions, translocates into the nucleus upon induction by electrophilic agents. |
Tissue Specificity | Widely expressed. Highest expression in liver, skeletal muscle, luminal cells of the stomach and intestine, lining of the bronchi and alveoli, and in renal tubules; followed by heart, spleen, testis and brain. |
Top Pathways | Protein processing in endoplasmic reticulum |
Recombinant Nuclear Factor, Erythroid Derived 2 Like Protein 2 (NFE2L2) - RPL947Mu01 from Cloud-clone
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Recombinant Mouse Nuclear factor erythroid 2-related factor 2(Nfe2l2) - CSB-YP726674MO CSB-EP726674MO CSB-BP726674MO CSB-MP726674MO from Cusabio
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Recombinant Mouse NFE2L2 Protein - NFE2L2-10615M from Creative Biomart
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Nuclear factor erythroid 2-related factor 2 (Nfe2l2), Recombinant Protein - MBS1368355 from MyBioSource
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