PRDX1

Gene Symbol PRDX1
Entrez Gene 5052
Alt Symbol MSP23, NKEF-A, NKEFA, PAG, PAGA, PAGB, PRX1, PRXI, TDPX2
Species Human
Gene Type protein-coding
Description peroxiredoxin 1
Other Description natural killer cell-enhancing factor A|natural killer-enhancing factor A|peroxiredoxin-1|proliferation-associated gene A|proliferation-associated gene protein|thioredoxin peroxidase 2|thioredoxin-dependent peroxide reductase 2
Swissprots Q5T155 Q2V576 B5BU26 Q06830 D3DPZ8 P35703 Q5T154
Accessions ABB84465 CAH59516 EAX06975 EAX06976 EAX06977 EAX06978 EAX06979 EAX06980 EAX06981 EAX06982 Q06830 AB451262 BAG70076 AB451388 BAG70202 AI912389 AK131049 AK311898 BAG34839 AV691526 BC007063 AAH07063 BC021683 AAH21683 BM740381 BM762399 BM787105 BM827394 BT019740 AAV38545 BU564066 CD638470 CR407652 CAG28580 DQ893173 ABM84099 DQ896472 ABM87471 L19184 AAA50464 X67951 CAA48137 NM_001202431 NP_001189360 NM_002574 NP_002565 NM_181696 NP_859047 NM_181697 NP_859048
Function Involved in redox regulation of the cell. Reduces peroxides with reducing equivalents provided through the thioredoxin system but not from glutaredoxin. May play an important role in eliminating peroxides generated during metabolism. Might participate in the signaling cascades of growth factors and tumor necrosis factor-alpha by regulating the intracellular concentrations of H(2)O(2). Reduces an intramolecular disulfide bond in GDPD5 that gates the ability to GDPD5 to drive postmitotic motor neuron differentiation (By similarity). {ECO:0000250}.
Subcellular Location Cytoplasm {ECO:0000269|PubMed:17081065}. Melanosome {ECO:0000269|PubMed:17081065}. Note=Identified by mass spectrometry in melanosome fractions from stage I to stage IV.
Top Pathways Peroxisome

Phospho-Prdx1 (Tyr194) (D1T9C) Rabbit mAb - 14041 from Cell Signaling Technology

Prices $287.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Monoclonal
Clone D1T9C
Western blot analysis of extracts from A-431 cells, untreated or treated with EGF (50 ng/ml, 15 min), λ phosphatase (13333 Unit/ml, overnight) using Phospho-Prdx1 (Tyr194) (D1T9C) Rabbit mAb (upper) and Prdx1 (D5G12) Rabbit mAb #8499 (lower).

Prdx1 (D5G12) Rabbit mAb - 8499 from Cell Signaling Technology

Prices $246.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Monoclonal
Clone D5G12
Western blot analysis of extracts from HeLa and MCF7 cells using Prdx1 (D5G12) Rabbit mAb.

Prdx1 Antibody - 8732 from Cell Signaling Technology

Host Rabbit
Clonality Polyclonal

PRX (C-6) - sc-271047 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
PRX (C-6): sc-271047. Western blot analysis of PRX II expression in non-transfected: sc-117752 (A) and mouse PRX II transfected: sc-122808 (B) 293T whole cell lysates.

PRX (B-11) - sc-137222 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
PRX (B-11): sc-137222. Western blot analysis of PRX II expression in non-transfected 293T: sc-117752 (A), mouse PRX II transfected 293T: sc-122808 (B) and MCF7 (C) whole cell lysates.

PRX (E-7) - sc-271020 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
PRX (E-7): sc-271020. Western blot analysis of PRX II expression in non-transfected: sc-117752 (A) and mouse PRX II transfected: sc-122808 (B) 293T whole cell lysates.

PRX (H-6) - sc-373961 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
PRX (H-6): sc-373961. Western blot analysis of PRX expression in MCF7 (A) and K-562 (B) whole cell lysates.

PRX I (N-19) - sc-7381 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
PRX I (N-19): sc-7381. Western blot analysis of PRX I expression in K-562 (A), U-937 (B) and RAW 264.7 (C) whole cell lysates.

PRX I (N-14) - sc-23965 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
PRX I (N-14): sc-23965. Western blot analysis of PRX I expression in K-562 (A), U-937 (B), MCF7 (C) and SK-N-MC (D) whole cell lysates.

PRX I (9D2) - sc-59657 from Santa Cruz Biotechnology

Prices $279.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
PRX I (9D2): sc-59657. Immunofluorescence staining of methanol-fixed HeLa cells showing cytoplasmic localization.

PRX I (2A4) - sc-59656 from Santa Cruz Biotechnology

Prices $279.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal

PRX I/II (H-40) - sc-33571 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
PRX I/II (H-40): sc-33571. Western blot analysis of PRX II expression in non-transfected 293T: sc-117752 (A), human PRX II transfected 293T: sc-117298 (B) and MCF7 (C) whole cell lysates.

Anti-Peroxiredoxin 1 antibody - ab58239 from Abcam

Prices $376.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal

Anti-Peroxiredoxin 1 antibody [13E7] - ab16745 from Abcam

Prices $378.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 13E7
Overlay histogram showing HeLa cells stained with ab16745 (red line). The cells were fixed with 80% methanol (5 min)/ and then permeabilized with 0.1% PBS-Tween for 20 min. The cells were then incubated in 1x PBS / 10% normal goat serum / 0.3M glycine to block non-specific protein-protein interactions followed by the antibody (ab16745, 0.1μg/1x106 cells) for 30 min at 22°C. The secondary antibody used was Alexa Fluor® 488 goat anti-mouse IgG (H&L) (ab150113) at 1/2000 dilution for 30 min at 22°C. Isotype control antibody (black line) was mouse IgG1 [ICIGG1] (ab91353, 1μg/1x106 cells) used under the same conditions. Unlabelled sample (blue line) was also used as a control. Acquisition of >5,000 events were collected using a 20mW Argon ion laser (488nm) and 525/30 bandpass filter. This antibody gave a positive signal in HeLa cells fixed with 4% formaldehyde (10 min)/permeabilized with 0.1% PBS-Tween for 20 min used under the same conditions.

Anti-Peroxiredoxin 1 antibody [2A4] - ab16746 from Abcam

Prices $370.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 2A4

Anti-Peroxiredoxin 1 antibody [3G5] - ab70666 from Abcam

Prices $378.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 3G5
All lanes : Anti-Peroxiredoxin 1 antibody [3G5] (ab70666) at 1/20000 dilutionLane 1 : HeLa cell lysateLane 2 : A431 cell lysateLane 3 : HL-60 cell lysateLane 4 : SK-N-MC cell lysate

Anti-Peroxiredoxin 1 antibody [9D2] - ab16747 from Abcam

Prices $370.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 9D2

Anti-Peroxiredoxin 1 antibody [EPR5433] - ab109498 from Abcam

Prices $388.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR5433
Overlay histogram showing HeLa cells stained with ab109498 (red line). The cells were fixed with 80% methanol (5 min) and then permeabilized with 0.1% PBS-Tween for 20 min. The cells were then incubated in 1x PBS / 10% normal goat serum / 0.3M glycine to block non-specific protein-protein interactions followed by the antibody (ab109498, 1/1000 dilution) for 30 min at 22°C. The secondary antibody used was Alexa Fluor® 488 goat anti-rabbit IgG (H+L) (ab150077) at 1/2000 dilution for 30 min at 22°C. Isotype control antibody (black line) was rabbit IgG (monoclonal) (1μg/1x106 cells) used under the same conditions. Unlabelled sample (blue line) was also used as a control. Acquisition of >5,000 events were collected using a 20mW Argon ion laser (488nm) and 525/30 bandpass filter.

Anti-Peroxiredoxin 1 antibody [EPR5434] - ab109506 from Abcam

Prices $385.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR5434
All lanes : Anti-Peroxiredoxin 1 antibody [EPR5434] (ab109506) at 1/10000 dilutionLane 1 : 293T cell lysate Lane 2 : K562 cell lysate Lane 3 : U87-MG cell lysateLysates/proteins at 10 µg per lane.SecondaryStandard HRP labelled goat anti-rabbit at 1/2000 dilution

Anti-PRDX1 / Peroxiredoxin 1 Antibody (aa104-115) - LS-C9562 from LifeSpan Bioscience

Prices $515.00
Sizes 50 µl
Host Rabbit
Clonality Polyclonal

Anti-PRDX1 / Peroxiredoxin 1 Antibody - LS-C113038 from LifeSpan Bioscience

Prices $315.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal

Anti-PRDX1 / Peroxiredoxin 1 Antibody (aa1-199) - LS-C126119 from LifeSpan Bioscience

Prices $465.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal

Anti-PRDX1 / Peroxiredoxin 1 Antibody - LS-C61939 from LifeSpan Bioscience

Prices $305.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal

Anti-PRDX1 / Peroxiredoxin 1 Antibody (aa1-199) - LS-C131358 from LifeSpan Bioscience

Prices $435.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal

Anti-PRDX1 / Peroxiredoxin 1 Antibody - LS-C131359 from LifeSpan Bioscience

Prices $475.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
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