Gene Symbol | Cd163 |
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Entrez Gene | 93671 |
Alt Symbol | CD163v2, CD163v3 |
Species | Mouse |
Gene Type | protein-coding |
Description | CD163 antigen |
Other Description | scavenger receptor cysteine-rich type 1 protein M130 |
Swissprots | Q99MX8 A6H691 Q2VLH6 Q2VLH5 |
Accessions | EDK99729 Q2VLH6 AF274883 AAK16065 AK032012 BC144848 AAI44849 BC145793 AAI45794 DQ058616 AAY99763 DQ058617 AAY99764 XM_006506800 XP_006506863 NM_001170395 NP_001163866 NM_053094 NP_444324 |
Function | Involved in clearance and endocytosis of hemoglobin/haptoglobin complexes by macrophages and may thereby protect tissues from free hemoglobin-mediated oxidative damage. May play a role in the uptake and recycling of iron, via endocytosis of hemoglobin/haptoglobin and subsequent breakdown of heme. Binds hemoglobin/haptoglobin complexes in a calcium- dependent and pH-dependent manner. Induces a cascade of intracellular signals that involves tyrosine kinase-dependent calcium mobilization, inositol triphosphate production and secretion of IL6 and CSF1 (By similarity). {ECO:0000250}. |
Subcellular Location | Soluble CD163: Secreted {ECO:0000250}. |
Tissue Specificity | Expressed in monocytes and mature macrophages such as Kupffer cells in the liver, red pulp macrophages in the spleen and mesenteric lymph nodes. {ECO:0000269|PubMed:11345593}. |
CD163 CRISPR/Cas9 KO Plasmid (m) - sc-429989 from Santa Cruz Biotechnology
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CD163 HDR Plasmid (m) - sc-429989-HDR from Santa Cruz Biotechnology
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CD163 Double Nickase Plasmid (m) - sc-429989-NIC from Santa Cruz Biotechnology
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CD163 Double Nickase Plasmid (m2) - sc-429989-NIC-2 from Santa Cruz Biotechnology
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CD163 CRISPR Activation Plasmid (m) - sc-429989-ACT from Santa Cruz Biotechnology
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CD163 CRISPR Activation Plasmid (m2) - sc-429989-ACT-2 from Santa Cruz Biotechnology
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CD163 Lentiviral Activation Particles (m) - sc-429989-LAC from Santa Cruz Biotechnology
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CD163 Lentiviral Activation Particles (m2) - sc-429989-LAC-2 from Santa Cruz Biotechnology
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CD163 siRNA (m) - sc-42835 from Santa Cruz Biotechnology
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CD163 shRNA Plasmid (m) - sc-42835-SH from Santa Cruz Biotechnology
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CD163 shRNA (m) Lentiviral Particles - sc-42835-V from Santa Cruz Biotechnology
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CompoZr® Knockout ZFN Kit - CKOZFN28308 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND28308 from Sigma-Aldrich
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CD163 siRNA (Mouse) - CRN0227 from Cohesion Biosciences
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CD163 - MBS8200935 from MyBioSource
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shRNA set against Mouse CD163 (NM_053094.2) - SHH258501 from Creative biogene
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CD163 shRNA Plasmid (Mouse) - CHN0227 from Cohesion Biosciences
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CD163 miRNA 3'UTR clone - MiUTR1M-02727 from Creative biogene
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