PPP1CA

Gene Symbol PPP1CA
Entrez Gene 5499
Alt Symbol PP-1A, PP1A, PP1alpha, PPP1A
Species Human
Gene Type protein-coding
Description protein phosphatase 1, catalytic subunit, alpha isozyme
Other Description protein phosphatase 1, catalytic subunit, alpha isoform|serine/threonine protein phosphatase PP1-alpha 1 catalytic subunit|serine/threonine-protein phosphatase PP1-alpha catalytic subunit
Swissprots B2R908 P62136 Q07161 A6NNR3
Accessions BAH56195 BAH69083 BAH69084 EAW74607 EAW74608 EAW74609 EAW74610 P62136 AK098311 AK127616 BAG54534 AK313586 BAG36355 AL557336 BC001888 AAH01888 BC004482 AAH04482 BC008010 AAH08010 BE278068 BE793459 BF526659 BG480286 BM799599 BM982080 BT006629 AAP35275 J04759 AAA36475 M63960 AAA36508 S57501 AAB26015 X70848 CAA50197 NM_001008709 NP_001008709 NM_002708 NP_002699 NM_206873 NP_996756
Function Protein phosphatase that associates with over 200 regulatory proteins to form highly specific holoenzymes which dephosphorylate hundreds of biological targets. Protein phosphatase 1 (PP1) is essential for cell division, and participates in the regulation of glycogen metabolism, muscle contractility and protein synthesis. Involved in regulation of ionic conductances and long-term synaptic plasticity. May play an important role in dephosphorylating substrates such as the postsynaptic density-associated Ca(2+)/calmodulin dependent protein kinase II. Component of the PTW/PP1 phosphatase complex, which plays a role in the control of chromatin structure and cell cycle progression during the transition from mitosis into interphase. Regulates NEK2 function in terms of kinase activity and centrosome number and splitting, both in the presence and absence of radiation-induced DNA damage. Regulator of neural tube and optic fissure closure, and enteric neural crest cell (ENCCs) migration during dev
Subcellular Location Cytoplasm. Nucleus. Nucleus, nucleoplasm. Nucleus, nucleolus. Note=Primarily nuclear and largely excluded from the nucleolus. Highly mobile in cells and can be relocalized through interaction with targeting subunits. NOM1 plays a role in targeting this protein to the nucleolus. In the presence of PPP1R8 relocalizes from the nucleus to nuclear speckles.
Top Pathways Amphetamine addiction, cGMP-PKG signaling pathway, Oxytocin signaling pathway, cAMP signaling pathway, Inflammatory mediator regulation of TRP channels

Human-PPP1CA-cDNA-Clone - DC00853 from Abgent, a WuXi AppTec company

Prices $445.50
Sizes 10 µg
Species Human
Accession NM_002708

PPP1CA - MBS1267013 from MyBioSource

Prices $175.00
Sizes 10ug plasmid + 200ul glycerol stock
Species Human
Accession BC001888

Human PPP1CA cDNA clone(NM_206873.1) - CDFG013606 from Creative Biomart

Species Human
Accession NM_206873.1

Human PPP1CA cDNA clone(NM_001008709.1) - CDFH014873 from Creative Biomart

Species Human
Accession NM_001008709.1

Human PPP1CA cDNA clone(NM_002708.3) - CDFH014874 from Creative Biomart

Species Human
Accession NM_002708.3

Human PPP1CA ORF Clone(NM_002708.3) - CDCL172517 from Creative Biomart

Species Human
Accession NM_002708.3

Human PPP1CA ORF Clone(NM_002708.3) - CDCR283867 from Creative Biomart

Species Human
Accession NM_002708.3

Human PPP1CA ORF Clone(NM_002708.3) - CDCR283868 from Creative Biomart

Species Human
Accession NM_002708.3

Human PPP1CA ORF Clone(NM_206873.1) - CDCR327647 from Creative Biomart

Species Human
Accession NM_206873.1

Human PPP1CA ORF Clone(NM_206873.1) - CDCR327648 from Creative Biomart

Species Human
Accession NM_206873.1

Human PPP1CA ORF Clone(NM_001008709.1) - CDCR340501 from Creative Biomart

Species Human
Accession NM_001008709.1

Human PPP1CA ORF Clone(NM_001008709.1) - CDCR340502 from Creative Biomart

Species Human
Accession NM_001008709.1

Human PPP1CA ORF Clone(NM_001008709.1) - CDCR340503 from Creative Biomart

Species Human
Accession NM_001008709.1
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