PPP1CA

Gene Symbol	PPP1CA
Entrez Gene	5499
Alt Symbol	PP-1A, PP1A, PP1alpha, PPP1A
Species	Human
Gene Type	protein-coding
Description	protein phosphatase 1, catalytic subunit, alpha isozyme
Other Description	protein phosphatase 1, catalytic subunit, alpha isoform|serine/threonine protein phosphatase PP1-alpha 1 catalytic subunit|serine/threonine-protein phosphatase PP1-alpha catalytic subunit
Swissprots	B2R908 P62136 Q07161 A6NNR3
Accessions	BAH56195 BAH69083 BAH69084 EAW74607 EAW74608 EAW74609 EAW74610 P62136 AK098311 AK127616 BAG54534 AK313586 BAG36355 AL557336 BC001888 AAH01888 BC004482 AAH04482 BC008010 AAH08010 BE278068 BE793459 BF526659 BG480286 BM799599 BM982080 BT006629 AAP35275 J04759 AAA36475 M63960 AAA36508 S57501 AAB26015 X70848 CAA50197 NM_001008709 NP_001008709 NM_002708 NP_002699 NM_206873 NP_996756
Function	Protein phosphatase that associates with over 200 regulatory proteins to form highly specific holoenzymes which dephosphorylate hundreds of biological targets. Protein phosphatase 1 (PP1) is essential for cell division, and participates in the regulation of glycogen metabolism, muscle contractility and protein synthesis. Involved in regulation of ionic conductances and long-term synaptic plasticity. May play an important role in dephosphorylating substrates such as the postsynaptic density-associated Ca(2+)/calmodulin dependent protein kinase II. Component of the PTW/PP1 phosphatase complex, which plays a role in the control of chromatin structure and cell cycle progression during the transition from mitosis into interphase. Regulates NEK2 function in terms of kinase activity and centrosome number and splitting, both in the presence and absence of radiation-induced DNA damage. Regulator of neural tube and optic fissure closure, and enteric neural crest cell (ENCCs) migration during dev
Subcellular Location	Cytoplasm. Nucleus. Nucleus, nucleoplasm. Nucleus, nucleolus. Note=Primarily nuclear and largely excluded from the nucleolus. Highly mobile in cells and can be relocalized through interaction with targeting subunits. NOM1 plays a role in targeting this protein to the nucleolus. In the presence of PPP1R8 relocalizes from the nucleus to nuclear speckles.
Top Pathways	Amphetamine addiction, cGMP-PKG signaling pathway, Oxytocin signaling pathway, cAMP signaling pathway, Inflammatory mediator regulation of TRP channels

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Active human PPP1A full length protein - ab128559 from Abcam Category Protein Prices $239.00 Sizes 5 µg Source Baculovirus infected sf9 cells Species Human

Active human PPP1A full length protein - ab113150 from Abcam Category Protein Prices $302.00 Sizes 10 µg Source E. coli Species Human

Active human PPP1A full length protein - ab167978 from Abcam Category Protein Prices $410.00 Sizes 10 µg Source E. coli Species Human

PPP1CA / PP1-Alpha Antibody Blocking Peptide - LS-E22853 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

PPP1CA / PP1-Alpha Antibody Blocking Peptide - LS-E21470 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

PP1 alpha/PPP1A Recombinant Protein - H00005499-P01 from Novus Biologicals Category Protein Prices $369.00 Sizes 10 µg Species Human

PP1 alpha/PPP1A Partial Recombinant Protein - H00005499-Q01 from Novus Biologicals Category Protein Prices $369.00 Sizes 10 µg Species Human

Recombinant Human PP1 alpha/PPP1A Protein - NBP1-72418 from Novus Biologicals Category Protein Prices $269.00, $729.00 Sizes 10 µg, 50 µg Source E. coli Species Human

PP1 alpha/PPP1A Peptide - P3320 from Novus Biologicals Category Peptide Species Human

PP1 alpha/PPP1A Peptide - P3319 from Novus Biologicals Category Peptide Species Human

PPP1CA-Antibody-N-term-Blocking-peptide - BP13424a from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

PPP1A-PPP1CA-Antibody-C-term-Blocking-peptide - BP8472b from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

PPP1A-PPP1CA-Antibody-N-term-Blocking-peptide - BP8472a from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

Human PPP1CA protein - orb169068 from Biorbyt Category Protein Prices $170.00, $289.00, $1,139.00 Sizes 1 μg, 5 μg, 50 μg Species Human

PPP1CA Blocking Peptide - 33R-6411 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

PPP1CA protein (His tag) - 80R-1935 from Fitzgerald Category Protein Prices $270.00 Sizes 10 µg Source E.coli

PPP1CA (1-330, His-tag) - AR39114PU-N from Acris Antibodies Category Protein Prices $790.00 Sizes 50 µg Source E. coli Species Human

PPP1CA (1-330, His-tag) - AR39114PU-S from Acris Antibodies Category Protein Prices $340.00 Sizes 10 µg Source E. coli Species Human

PPP1CA - H00005499-P01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

PPP1CA - H00005499-P01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

PPP1CA - H00005499-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

PPP1CA - H00005499-Q01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

PPP1CA, 1-330aa, Human, His tag, E.coli - 01-2345-CA from ARP American Research Products Category Protein Prices $159.00, $369.00, $849.00 Sizes 2 µg, 10 µg, 50 µg Species Human

PPP1CA Human - ENPS-172 from NeoScientific Category Protein Prices $65.00, $169.00, $1,560.00 Sizes 1 µg, 5 µg, 50 µg Source Escherichia Coli. Species Human

Recombinant Human Protein Phosphatase 1, Catalytic Subunit Alpha - BP002719-ENZ-165 from Syd Labs Category Protein Prices $160.00, $1,200.00 Sizes 5 µg, 50 µg Source E. coli-derived. Species Human

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