PPP1CA

Gene Symbol PPP1CA
Entrez Gene 5499
Alt Symbol PP-1A, PP1A, PP1alpha, PPP1A
Species Human
Gene Type protein-coding
Description protein phosphatase 1, catalytic subunit, alpha isozyme
Other Description protein phosphatase 1, catalytic subunit, alpha isoform|serine/threonine protein phosphatase PP1-alpha 1 catalytic subunit|serine/threonine-protein phosphatase PP1-alpha catalytic subunit
Swissprots B2R908 P62136 Q07161 A6NNR3
Accessions BAH56195 BAH69083 BAH69084 EAW74607 EAW74608 EAW74609 EAW74610 P62136 AK098311 AK127616 BAG54534 AK313586 BAG36355 AL557336 BC001888 AAH01888 BC004482 AAH04482 BC008010 AAH08010 BE278068 BE793459 BF526659 BG480286 BM799599 BM982080 BT006629 AAP35275 J04759 AAA36475 M63960 AAA36508 S57501 AAB26015 X70848 CAA50197 NM_001008709 NP_001008709 NM_002708 NP_002699 NM_206873 NP_996756
Function Protein phosphatase that associates with over 200 regulatory proteins to form highly specific holoenzymes which dephosphorylate hundreds of biological targets. Protein phosphatase 1 (PP1) is essential for cell division, and participates in the regulation of glycogen metabolism, muscle contractility and protein synthesis. Involved in regulation of ionic conductances and long-term synaptic plasticity. May play an important role in dephosphorylating substrates such as the postsynaptic density-associated Ca(2+)/calmodulin dependent protein kinase II. Component of the PTW/PP1 phosphatase complex, which plays a role in the control of chromatin structure and cell cycle progression during the transition from mitosis into interphase. Regulates NEK2 function in terms of kinase activity and centrosome number and splitting, both in the presence and absence of radiation-induced DNA damage. Regulator of neural tube and optic fissure closure, and enteric neural crest cell (ENCCs) migration during dev
Subcellular Location Cytoplasm. Nucleus. Nucleus, nucleoplasm. Nucleus, nucleolus. Note=Primarily nuclear and largely excluded from the nucleolus. Highly mobile in cells and can be relocalized through interaction with targeting subunits. NOM1 plays a role in targeting this protein to the nucleolus. In the presence of PPP1R8 relocalizes from the nucleus to nuclear speckles.
Top Pathways Amphetamine addiction, cGMP-PKG signaling pathway, Oxytocin signaling pathway, cAMP signaling pathway, Inflammatory mediator regulation of TRP channels

Phospho-PP1α (Thr320) Antibody - 2581 from Cell Signaling Technology

Prices $287.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Polyclonal
Western blot analysis of Recombinant PP1α, incubated with or without cdc2 protein kinase in the presence of ATP and kinase assay buffer at 30ºC for 30 minutes, using Phospho-PP1α (Thr320) Antibody (upper) or control PP1α Antibody #2582 (lower).

PP1α Antibody - 2582 from Cell Signaling Technology

Prices $246.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Polyclonal
Western blot analysis of purified recombinant PP1α protein (lane 1), and extracts from C6, NIH/3T3 and HeLa cells (lanes 2-4), using PP1α Antibody.

PP1 (E-9) - sc-7482 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
PP1 (E-9): sc-7482. Western blot analysis of PP1 expression in HISM (A) and C32 (B) whole cell lysates.

PP1α (C-19) - sc-6104 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
PP1α (C-19): sc-6104. Western blot analysis of PP1α expression in BT-20 (A), SK-BR-3 (B), Jurkat (C), BC<sub>3</sub>H1 (D), KNRK (E), NIH/3T3 (F), A-10 (G) and PC-12 (H) cell lysates.

PP1α (G-4) - sc-271762 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
PP1α (G-4): sc-271762. Western blot analysis of PP1α expression in NIH/3T3 whole cell lysate.

PP1α (N-19) - sc-6105 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
PP1α (N-19): sc-6105. Western blot analysis of PP1α expression in C32 (A), Hep G2 (B), A-431 (C), KNRK (D) and NIH/3T3 (E) whole cell lysates.

PP1α (FL-18) - sc-443 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
PP1α (FL-18): sc-443. Western blot analysis of PP1α expression in KNRK (A), Jurkat (B) and NIH/3T3 (C) whole cell lysates.

Anti-PPP1A (phospho T320) antibody - ab62203 from Abcam

Prices $376.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Immunohistochemical analysis of paraffin-embedded human breast carcinoma tissue using PPP1A (phospho T320) antibody (ab62203) at 1/50 - 1/100 dilution, in the presence (right hand panel) or absence (left hand panel) of immunising phosphopeptide.

Anti-PPP1A (phospho T320) antibody - ab138396 from Abcam

Prices $376.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Anti-PPP1A (phospho T320) antibody (ab138396) at 1/500 dilution + Jurkat cell extract at 30 µg

Anti-PPP1A (phospho T320) antibody [EP1512Y] - ab62334 from Abcam

Prices $385.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EP1512Y
All lanes : Anti-PPP1A (phospho T320) antibody [EP1512Y] (ab62334)Lane 1 : HeLa cell lysate (untreated)Lane 2 : HeLa cell lysate (treated with Calyculin A)Lysates/proteins at 10 µg per lane.SecondaryGoat anti-rabbit HRP conjugate at 1/2000 dilution

Anti-PPP1A antibody - ab62625 from Abcam

Prices $376.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Immunohistochemistry analysis of paraffin-embedded human breast carcinoma tissue using ab62625 at a 1:50 dilution.Left image untreated.Right image treated with peptide.

Anti-PPP1A antibody - ab64321 from Abcam

Prices $370.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-PPP1A antibody - ab33620 from Abcam

Prices $370.00
Sizes 500 µg
Host Chicken
Clonality Polyclonal

Anti-PPP1A antibody [1C11-C10-H5-E9] - ab150782 from Abcam

Prices $384.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 1C11-C10-H5-E9
All lanes : Anti-PPP1A antibody [1C11-C10-H5-E9] (ab150782) at 1/1000 dilutionLane 1 : A431 whole cell lysatesLane 2 : Jurkat whole cell lysatesLane 3 : HeLa whole cell lysates

Anti-PPP1A antibody [1H1-F7-D8] - ab151265 from Abcam

Prices $376.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 1H1-F7-D8
All lanes : Anti-PPP1A antibody [1H1-F7-D8] (ab151265) at 1/1000 dilutionLane 1 : HepG2 cell lysateLane 2 : MCF7 cell lysateLane 3 : HeLa cell lysate

Anti-PPP1A antibody [4G3] - ab66955 from Abcam

Prices $376.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 4G3
Anti-PPP1A antibody [4G3] (ab66955) at 1/1000 dilution + HepG2 cell lysate at 45 µgSecondarygoat anti-mousedeveloped using the ECL technique

Anti-PPP1A antibody [6D1] - ab105921 from Abcam

Host Mouse
Clonality Monoclonal
Clone 6D1
All lanes : Anti-PPP1A antibody [6D1] (ab105921) at 1/500 dilutionLane 1 : HeLa cell lysateLane 2 : NIH/3T3 cell lysate

Anti-PPP1CA + 1CB antibody [EP1511Y] - ab52619 from Abcam

Prices $391.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EP1511Y
ab52619 (purified) at 1/30 immunoprecipitating PPP1CA + 1CB in Jurkat cell lysate. For western blotting, a HRP-conjugated Goat anti-rabbit IgG, specific to the non-reduced form of IgG was used as the secondary antibody (1/1000).Blocking buffer and concentration: 5% NFDM/TBST.Diluting buffer and concentration: 5% NFDM /TBST.

Anti-PPP1CA / PP1-Alpha Antibody (aa30-299, clone 4G3) IHC-plus™ - LS-B2944 from LifeSpan Bioscience

Prices $395.00
Sizes 50 µg
Host Mouse
Clonality Monoclonal
Clone 4G3
Anti-PPP1CA antibody IHC of human brain, cortex. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B2944 concentration 5 ug/ml.

Anti-PPP1CA / PP1-Alpha Antibody (C-Terminus) - LS-C144719 from LifeSpan Bioscience

Prices $365.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-PPP1CA / PP1-Alpha Antibody - LS-C154752 from LifeSpan Bioscience

Prices $330.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-PPP1CA / PP1-Alpha Antibody (clone PP-1A, Magnetic beads) - LS-C171262 from LifeSpan Bioscience

Prices $325.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone PP-1A

Anti-PPP1CA / PP1-Alpha Antibody (clone PP-1A) - LS-C171261 from LifeSpan Bioscience

Prices $295.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone PP-1A

Anti-PPP1CA / PP1-Alpha Antibody (clone PP-1A, Sepharose) - LS-C171263 from LifeSpan Bioscience

Prices $325.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone PP-1A

Anti-PPP1CA / PP1-Alpha Antibody (clone 6D1) - LS-C169202 from LifeSpan Bioscience

Prices $320.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 6D1
Western blot using PPP1A mouse monoclonal antibody against HeLa (1) and NIH/3T3 (2) cell lysate.
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