| Gene Symbol |
Jup
|
| Entrez Gene |
16480
|
| Alt Symbol |
Ctnng, D930025P04Rik, PG
|
| Species |
Mouse
|
| Gene Type |
protein-coding
|
| Description |
junction plakoglobin
|
| Other Description |
desmoplakin III|desmoplakin-3|gamma-catenin
|
| Swissprots |
Q02257 Q8CGD3
|
| Accessions |
CAP07505 CAP11473 CAR97087 CAT82325 EDL02564 Q02257 AK086401 AK145895 AK170934 BAE42126 AK171501 BC040757 AAH40757 BC094461 AAH94461 CD555608 M90365 AAB02885 XM_006532315 XP_006532378 XM_006532316 XP_006532379 NM_010593 NP_034723
|
| Function |
Common junctional plaque protein. The membrane- associated plaques are architectural elements in an important strategic position to influence the arrangement and function of both the cytoskeleton and the cells within the tissue. The presence of plakoglobin in both the desmosomes and in the intermediate junctions suggests that it plays a central role in the structure and function of submembranous plaques. Acts as a substrate for VE-PTP and is required by it to stimulate VE- cadherin function in endothelial cells. Can replace beta-catenin in E-cadherin/catenin adhesion complexes which are proposed to couple cadherins to the actin cytoskeleton. {ECO:0000269|PubMed:19015309}.
|
| Subcellular Location |
Cell junction, adherens junction. Cell junction, desmosome. Cytoplasm, cytoskeleton. Membrane; Peripheral membrane protein. Note=Cytoplasmic in a soluble and membrane- associated form.
|
| Top Pathways |
Acute myeloid leukemia, Arrhythmogenic right ventricular cardiomyopathy (ARVC), Transcriptional misregulation in cancer
|