Gene Symbol | Jup |
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Entrez Gene | 16480 |
Alt Symbol | Ctnng, D930025P04Rik, PG |
Species | Mouse |
Gene Type | protein-coding |
Description | junction plakoglobin |
Other Description | desmoplakin III|desmoplakin-3|gamma-catenin |
Swissprots | Q02257 Q8CGD3 |
Accessions | CAP07505 CAP11473 CAR97087 CAT82325 EDL02564 Q02257 AK086401 AK145895 AK170934 BAE42126 AK171501 BC040757 AAH40757 BC094461 AAH94461 CD555608 M90365 AAB02885 XM_006532315 XP_006532378 XM_006532316 XP_006532379 NM_010593 NP_034723 |
Function | Common junctional plaque protein. The membrane- associated plaques are architectural elements in an important strategic position to influence the arrangement and function of both the cytoskeleton and the cells within the tissue. The presence of plakoglobin in both the desmosomes and in the intermediate junctions suggests that it plays a central role in the structure and function of submembranous plaques. Acts as a substrate for VE-PTP and is required by it to stimulate VE- cadherin function in endothelial cells. Can replace beta-catenin in E-cadherin/catenin adhesion complexes which are proposed to couple cadherins to the actin cytoskeleton. {ECO:0000269|PubMed:19015309}. |
Subcellular Location | Cell junction, adherens junction. Cell junction, desmosome. Cytoplasm, cytoskeleton. Membrane; Peripheral membrane protein. Note=Cytoplasmic in a soluble and membrane- associated form. |
Top Pathways | Acute myeloid leukemia, Arrhythmogenic right ventricular cardiomyopathy (ARVC), Transcriptional misregulation in cancer |
Junction plakoglobin (JUP), Mouse, ELISA Kit - E03J0005 from ARP American Research Products
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Pg (Progesterone), Mouse, ELISA Kit - E-EL-M0945 from ARP American Research Products
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Mouse PG ELISA Kit - MP0168 from NeoScientific
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Junction Plakoglobin, ELISA Kit - MBS070475 from MyBioSource
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Pg, ELISA Kit - MBS2507099 from MyBioSource
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Mouse Pg (Progesterone) ELISA Kit - E-EL-M0945 from Elabscience
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Mouse Pg (Progesterone) CLIA Kit - E-CL-M0570 from Elabscience
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Mouse Proteoglycans ELISA - E03P0161 from BlueGene Biotech
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Mouse Pg (Progesterone) CLIA Kit - E-CL-M0570 from Iwai North America Inc.
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Pg (Progesterone), CLIA Kit - MBS2531336 from MyBioSource
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Pg - EKM2562 from Nordic BioSite
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Mouse Jup ELISA Kit - E046280 from Biobool
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Mouse PG ELISA Kit - E065433 from Biobool
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Mouse PG ELISA Kit - EMP0168 from ABclonal
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Mouse Pepsin (PG) ELISA Kit - AE27868MO from ARP American Research Products
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Junction plakoglobin, ELISA Kit - MBS2885585 from MyBioSource
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