Gene Symbol | Jup |
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Entrez Gene | 16480 |
Alt Symbol | Ctnng, D930025P04Rik, PG |
Species | Mouse |
Gene Type | protein-coding |
Description | junction plakoglobin |
Other Description | desmoplakin III|desmoplakin-3|gamma-catenin |
Swissprots | Q02257 Q8CGD3 |
Accessions | CAP07505 CAP11473 CAR97087 CAT82325 EDL02564 Q02257 AK086401 AK145895 AK170934 BAE42126 AK171501 BC040757 AAH40757 BC094461 AAH94461 CD555608 M90365 AAB02885 XM_006532315 XP_006532378 XM_006532316 XP_006532379 NM_010593 NP_034723 |
Function | Common junctional plaque protein. The membrane- associated plaques are architectural elements in an important strategic position to influence the arrangement and function of both the cytoskeleton and the cells within the tissue. The presence of plakoglobin in both the desmosomes and in the intermediate junctions suggests that it plays a central role in the structure and function of submembranous plaques. Acts as a substrate for VE-PTP and is required by it to stimulate VE- cadherin function in endothelial cells. Can replace beta-catenin in E-cadherin/catenin adhesion complexes which are proposed to couple cadherins to the actin cytoskeleton. {ECO:0000269|PubMed:19015309}. |
Subcellular Location | Cell junction, adherens junction. Cell junction, desmosome. Cytoplasm, cytoskeleton. Membrane; Peripheral membrane protein. Note=Cytoplasmic in a soluble and membrane- associated form. |
Top Pathways | Acute myeloid leukemia, Arrhythmogenic right ventricular cardiomyopathy (ARVC), Transcriptional misregulation in cancer |
SignalSilence ® γ-Catenin siRNA II (Mouse Specific) - 12680 from Cell Signaling Technology
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SignalSilence ® γ-Catenin siRNA I (Mouse Specific) - 12523 from Cell Signaling Technology
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γ-catenin CRISPR/Cas9 KO Plasmid (m) - sc-421210 from Santa Cruz Biotechnology
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γ-catenin HDR Plasmid (m) - sc-421210-HDR from Santa Cruz Biotechnology
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γ-catenin Double Nickase Plasmid (m) - sc-421210-NIC from Santa Cruz Biotechnology
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γ-catenin Double Nickase Plasmid (m2) - sc-421210-NIC-2 from Santa Cruz Biotechnology
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γ-catenin CRISPR Activation Plasmid (m) - sc-421210-ACT from Santa Cruz Biotechnology
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γ-catenin CRISPR Activation Plasmid (m2) - sc-421210-ACT-2 from Santa Cruz Biotechnology
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γ-catenin Lentiviral Activation Particles (m) - sc-421210-LAC from Santa Cruz Biotechnology
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γ-catenin Lentiviral Activation Particles (m2) - sc-421210-LAC-2 from Santa Cruz Biotechnology
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γ-catenin siRNA (m) - sc-29932 from Santa Cruz Biotechnology
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γ-catenin shRNA Plasmid (m) - sc-29932-SH from Santa Cruz Biotechnology
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γ-catenin shRNA (m) Lentiviral Particles - sc-29932-V from Santa Cruz Biotechnology
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CompoZr® Knockout ZFN Kit - CKOZFN34081 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND34081 from Sigma-Aldrich
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JUP siRNA (Mouse) - CRM2155 from Cohesion Biosciences
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JUP, siRNA - MBS8229055 from MyBioSource
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shRNA set against Mouse JUP (NM_010593.2) - SHH322315 from Creative biogene
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Mouse JUP siRNA - orb281631 from Biorbyt
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JUP shRNA Plasmid (Mouse) - CHM2155 from Cohesion Biosciences
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