Fga
| Gene Symbol | Fga |
|---|---|
| Entrez Gene | 361969 |
| Alt Symbol | Ac1873, Fba5e |
| Species | Rat |
| Gene Type | protein-coding |
| Description | fibrinogen alpha chain |
| Other Description | fibrinogen, A alpha polypeptide|fibrinogen, alpha polypeptide |
| Swissprots | P06399 |
| Accessions | CAA60263 CAA60264 EDM00839 P06399 AY310161 AAP78769 BC098766 AAH98766 BC127465 AAI27466 FQ209852 M35601 AAA41158 XM_006232532 XP_006232594 XM_006232533 XP_006232595 NM_001008724 NP_001008724 NM_052797 NP_434684 |
| Function | Cleaved by the protease thrombin to yield monomers which, together with fibrinogen beta (FGB) and fibrinogen gamma (FGG), polymerize to form an insoluble fibrin matrix. Fibrin has a major function in hemostasis as one of the primary components of blood clots. In addition, functions during the early stages of wound repair to stabilize the lesion and guide cell migration during re-epithelialization. Was originally thought to be essential for platelet aggregation, based on in vitro studies using anticoagulated blood. However, subsequent studies have shown that it is not absolutely required for thrombus formation in vivo. Enhances expression of SELP in activated platelets via an ITGB3- dependent pathway. Maternal fibrinogen is essential for successful pregnancy. Fibrin deposition is also associated with infection, where it protects against IFNG-mediated hemorrhage. May also facilitate the immune response via both innate and T-cell mediated pathways. {ECO:0000250|UniProtKB:E9PV24}. |
| Subcellular Location | Secreted. |
| Top Pathways | Complement and coagulation cascades |
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