ENPP2

Gene Symbol	ENPP2
Entrez Gene	5168
Alt Symbol	ATX, ATX-X, AUTOTAXIN, LysoPLD, NPP2, PD-IALPHA, PDNP2
Species	Human
Gene Type	protein-coding
Description	ectonucleotide pyrophosphatase/phosphodiesterase 2
Other Description	E-NPP 2|autotaxin-t|ectonucleotide pyrophosphatase/phosphodiesterase family member 2|extracellular lysophospholipase D|phosphodiesterase I/nucleotide pyrophosphatase 2|plasma lysophospholipase D
Swissprots	Q15117 A8UHA1 Q13827 Q9UCR0 Q14555 Q13822 Q9UCR4 E9PHP7 Q9UCR1 Q9UCR3 Q9UCR2 Q9UCQ8
Accessions	AAB00855 BAA08342 CCF77047 CCF77048 CCF77049 CCQ43347 EAW91986 EAW91987 EAW91988 EAW91989 EAW91990 Q13822 AA256687 AI339551 AI375195 AK124910 AK130313 AK296027 BAG58795 AK315253 AL544867 BC034961 AAH34961 BM694754 BQ365938 BU731264 CA390514 D45421 BAA08260 DA919550 DA922156 DB468753 DC338843 DQ891628 ABM82554 DQ894819 ABM85745 EU131011 ABW38316 L35594 AAA64785 XM_006716584 XP_006716647 XM_006716585 XP_006716648 XM_006716586 XP_006716649 XM_006716587 XP_006716650 NM_001040092 NP_001035181 NM_001130863 NP_001124335 NM_006209 NP_006200 NR_045555
Function	Hydrolyzes lysophospholipids to produce lysophosphatidic acid (LPA) in extracellular fluids. Major substrate is lysophosphatidylcholine. Also can act on sphingosylphosphphorylcholine producing sphingosine-1-phosphate, a modulator of cell motility. Can hydrolyze, in vitro, bis-pNPP, to some extent pNP-TMP, and barely ATP. Involved in several motility- related processes such as angiogenesis and neurite outgrowth. Acts as an angiogenic factor by stimulating migration of smooth muscle cells and microtubule formation. Stimulates migration of melanoma cells, probably via a pertussis toxin-sensitive G protein. May have a role in induction of parturition. Possible involvement in cell proliferation and adipose tissue development. Tumor cell motility-stimulating factor. {ECO:0000269|PubMed:11559573, ECO:0000269|PubMed:1733949, ECO:0000269|PubMed:21240271}.
Subcellular Location	Secreted {ECO:0000269|PubMed:15769751}. Note=Secreted by most body fluids including serum and CSF. Also by adipocytes and numerous cancer cells.
Tissue Specificity	Predominantly expressed in brain, placenta, ovary, and small intestine. Expressed in a number of carcinomas such as hepatocellular and prostate carcinoma, neuroblastoma and non-small-cell lung cancer. Expressed in body fluids such as plasma, cerebral spinal fluid (CSF), saliva, follicular and amniotic fluids. Not detected in leukocytes. Isoform 1 is more highly expressed in peripheral tissues than in the central nervous system (CNS). Adipocytes only express isoform 1. Isoform 3 is more highly expressed in the brain than in peripheral tissues. {ECO:0000269|PubMed:18175805, ECO:0000269|PubMed:8579579, ECO:0000269|PubMed:8586446}.
Top Pathways	Ether lipid metabolism

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human ENPP2 / Autotaxin ELISA Kit (Sandwich ELISA) - LS-F6666 from LifeSpan Bioscience Category ELISA Kit Prices $720.00 Sizes 1 plate Sensitivity 43.21 pg/ml Range 93.75-6000 pg/ml

Human ENPP-2/Autotaxin Quantikine ELISA Kit - DENP20 from R&D Systems Category ELISA Kit Prices $519.00 Sizes 1 kit Sensitivity 0.157 ng/mL Range 0.8 - 50 ng/mL (Cell Culture Supernates, Serum, Heparin Plasma, Urine, Human Milk)

Human ENPP-2/Autotaxin DuoSet ELISA - DY5255-05 from R&D Systems Category ELISA Kit Prices $299.00 Sizes 1 kit (for 5 Plates) Range 78.10 - 5,000 pg/mL

Quantikine Immunoassay Control Set 701 for Human ENPP-2 - QC84 from R&D Systems Category ELISA Kit Prices $125.00 Sizes 1 each

Human ENPP2 ELISA Kit - abx151417 from Abbexa Category ELISA Kit Sensitivity 42.16 pg/ml Range 93.75 pg/ml - 6000 pg/ml

Ectonucleotide Pyrophosphatase/Phosphodiesterase 2 (ENPP2), Human, ELISA Kit - SEC323Hu from ARP American Research Products Category ELISA Kit Prices $720.00 Sizes 96 t Sensitivity 32.28pg/mL Range 93.75-6,000pg/mL

Ectonucleotide pyrophosphatase/phosphodiesterase family member 2 (ENPP2), Human, ELISA Kit - CSB-EL007680HU from ARP American Research Products Category ELISA Kit Prices $495.00, $695.00, $696.00, $699.00 Sizes 48 t, 96 t, 5 x 96t, 10 x 96t Sensitivity 6.25 pg/ml Range 25 pg/ml-1600 pg/ml

Ectonucleotide pyrophosphatase/phosphodiesterase family member 2, ENPP2, Human, ELISA Kit - E1228h from ARP American Research Products Category ELISA Kit Prices $476.00 Sizes 96 t Range 1.25-80 ng/mL

Ectonucleotide Pyrophosphatase/Phosphodiesterase 2 (ENPP2), ELISA Kit - MBS2022398 from MyBioSource Category ELISA Kit Prices $380.00, $565.00, $765.00, $3,130.00, $5,670.00 Sizes 24 -strip-wells, 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity Typically less than 43.21pg/mL. Range 93.75-6000pg/mL

Human ENPP-2 ELISA Kit - DEIA2834 from Creative Diagnostics Category ELISA Kit Sensitivity Twenty-two assays were evaluated and the minimum detectable dose (MDD) of ENPP-2 ranged from 0.055 - 0.157 ng/mL. The mean MDD was 0.093 ng/mL. The MDD was determined by adding two standard deviations to the mean optical density value of twenty zero st

Ectonucleotide Pyrophosphatase/Phosphodiesterase 2, ELISA Kit - MBS056576 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Ectonucleotide Pyrophosphatase/Phosphodiesterase 2, ELISA Kit - MBS078861 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Ectonucleotide Pyrophosphatase/Phosphodiesterase 2, ELISA Kit - MBS090214 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Ectonucleotide Pyrophosphatase/Phosphodiesterase 2, ELISA Kit - MBS088450 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Ectonucleotide Pyrophosphatase/Phosphodiesterase 2, ELISA Kit - MBS071558 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

ectonucleotide pyrophosphatase/phosphodiesterase 2, ELISA Kit - MBS930753 from MyBioSource Category ELISA Kit Prices $250.00, $495.00, $710.00, $2,705.00, $5,145.00 Sizes 24 -strip-wells (Limit 1), 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity 50ng/ml Range 50ng/ml-2000 ng/ml

Ectonucleotide Pyrophosphatase/Phosphodiesterase 2, ELISA Kit - MBS077259 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Ectonucleotide Pyrophosphatase/Phosphodiesterase 2, ELISA Kit - MBS105435 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Ectonucleotide Pyrophosphatase/Phosphodiesterase 2 (ENPP2), ELISA Kit - MBS2025147 from MyBioSource Category ELISA Kit Prices $405.00, $605.00, $820.00, $3,375.00, $6,125.00 Sizes 24 -strip-wells, 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity Typically less than 0.067ng/mL. Range 0.156-10ng/mL

ELISA Kit for Ectonucleotide Pyrophosphatase/Phosphodiesterase 2 (ENPP2) - SEC323Hu from Uscn Life Science Inc. Category ELISA Kit Sensitivity The minimum detectable dose of this kit is typically less than 43.21pg/mL. Range 93.75-6000pg/mL The standard curve concentrations used for the ELISA’s were 6000pg/mL, 3000pg/mL, 1500pg/mL, 750pg/mL, 375pg/mL, 187.5pg/mL, 93.75pg/mL

ELISA Kit for Ectonucleotide Pyrophosphatase/Phosphodiesterase 2 (ENPP2) - SEC323Mu from Uscn Life Science Inc. Category ELISA Kit Sensitivity The minimum detectable dose of this kit is typically less than 35pg/mL. Range 78.13-5000pg/mL The standard curve concentrations used for the ELISA’s were 5000pg/mL, 2500pg/mL, 1250pg/mL, 625pg/mL, 312.5pg/mL, 156.25pg/mL, 78.13pg/mL

ELISA Kit for Ectonucleotide Pyrophosphatase/Phosphodiesterase 2 (ENPP2) - SEC323Ra from Uscn Life Science Inc. Category ELISA Kit Sensitivity The minimum detectable dose of this kit is typically less than 0.067ng/mL. Range 0.156-10ng/mL The standard curve concentrations used for the ELISA’s were 10ng/mL, 5ng/mL, 2.5ng/mL, 1.25ng/mL, 0.625ng/mL, 0.313ng/mL, 0.156ng/mL

Human Ectonucleotide pyrophosphatase/phosphodiesterase family member 2(ENPP2) EL - CSB-EL007680HU from Cusabio Sensitivity 31.25 ng/ml Range 25 ng/ml-2000 ng/ml

ELISA Kit for Ectonucleotide Pyrophosphatase/Phosphodiesterase 2 (ENPP2) - SEC323Hu from Cloud-clone Category ELISA Kit Sensitivity The minimum detectable dose of this kit is typically less than 43.21pg/mL. Range 93.75-6000pg/mL The standard curve concentrations used for the ELISA's were 6000pg/mL, 3000pg/mL, 1500pg/mL, 750pg/mL, 375pg/mL, 187.5pg/mL, 93.75pg/mL

Bovine ENPP2 / Autotaxin ELISA Kit (Custom ELISA) - LS-F16527 from LifeSpan Bioscience Category ELISA Kit Prices $700.00 Sizes 1 plate Sensitivity To be determined Range 93.75-6000 pg/ml

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