| Gene Symbol |
ZW10
|
| Entrez Gene |
9183
|
| Alt Symbol |
HZW10, KNTC1AP
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
zw10 kinetochore protein
|
| Other Description |
ZW10 homolog, centromere/kinetochore protein|ZW10, kinetochore associated, homolog|centromere/kinetochore protein zw10 homolog|zeste white 10 homolog
|
| Swissprots |
O43264 A1A528
|
| Accessions |
EAW67229 O43264 AK300746 BAG62415 AK303871 BAG64809 AK312925 BAG35769 BC128264 AAI28265 BI547129 BM833775 BQ773926 DB506745 U54996 AAB88237 NM_004724 NP_004715
|
| Function |
Essential component of the mitotic checkpoint, which prevents cells from prematurely exiting mitosis. Required for the assembly of the dynein-dynactin and MAD1-MAD2 complexes onto kinetochores. Involved in regulation of membrane traffic between the Golgi and the endoplasmic reticulum. {ECO:0000269|PubMed:11590237, ECO:0000269|PubMed:15029241, ECO:0000269|PubMed:15094189, ECO:0000269|PubMed:15485811, ECO:0000269|PubMed:15824131}.
|
| Subcellular Location |
Cytoplasm. Endoplasmic reticulum membrane; Peripheral membrane protein. Chromosome, centromere, kinetochore. Cytoplasm, cytoskeleton, spindle. Note=Dynamic pattern of localization during the cell cycle. In most cells at interphase, present diffusely in the cytoplasm. In prometaphase, associated with the kinetochore. At metaphase, detected both at the kinetochores and, most prominently, at the spindle, particularly at the spindle poles. In very early anaphase, detected on segregating kinetochores. In late anaphase and telophase, accumulates at the spindle midzone.
|
| Tissue Specificity |
Widely expressed.
|