| Gene Symbol | CCKBR |
|---|---|
| Entrez Gene | 887 |
| Alt Symbol | CCK-B, CCK2R, GASR |
| Species | Human |
| Gene Type | protein-coding |
| Description | cholecystokinin B receptor |
| Other Description | CCK-B receptor|CCK-BR|CCK2 receptor|CCK2-R|cholecystokinin-2 receptor|gastrin receptor|gastrin/cholecystokinin type B receptor |
| Swissprots | Q9UBV1 Q96LC6 Q9NYK7 O75824 P32239 Q16144 A8K7P9 Q92492 |
| Accessions | AAC37528 AAD14956 BAA04759 EAW68734 EAW68735 P32239 AF239668 AAF67174 AF441129 AAN32829 AK226020 AK292064 BAF84753 AK314266 AY029770 AAK38351 AY322551 AAP84364 BC000740 AAH00740 BT006789 AAP35435 CX762706 D13305 BAA02564 DA297178 DQ335648 ABC86718 DQ335649 ABC86719 DQ335650 ABC86720 DQ335651 ABC86721 DQ890577 ABM92194 DQ893737 ABM84663 L04473 AAA35660 L07746 AAA91831 L08112 AAA35657 S70057 AAB30766 S76072 AAB33740 Y13464 XM_005253210 XP_005253267 XM_011520443 XP_011518745 NM_176875 NP_795344 |
| Function | Receptor for gastrin and cholecystokinin. The CKK-B receptors occur throughout the central nervous system where they modulate anxiety, analgesia, arousal, and neuroleptic activity. This receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. |
| Subcellular Location | Cell membrane; Multi-pass membrane protein. |
| Tissue Specificity | Isoform 1 is expressed in brain, pancreas, stomach, the colon cancer cell line LoVo and the T-lymphoblastoma Jurkat, but not in heart, placenta, liver, lung, skeletal muscle, kidney or the stomach cancer cell line AGS. Expressed at high levels in the small cell lung cancer cell line NCI-H510, at lower levels in NCI-H345, NCI-H69 and GLC-28 cell lines, not expressed in GLC-19 cell line. Within the stomach, expressed at high levels in the mucosa of the gastric fundus and at low levels in the antrum and duodenum. Isoform 2 is present in pancreatic cancer cells and colorectal cancer cells, but not in normal pancreas or colonic mucosa. Isoform 3 is expressed in brain, pancreas, stomach, the stomach cancer cell line AGS and the colon cancer cell line LoVo. {ECO:0000269|PubMed:10913157, ECO:0000269|PubMed:12429993, ECO:0000269|PubMed:7848914, ECO:0000269|PubMed:7887934, ECO:0000269|PubMed:8185170, ECO:0000269|PubMed:8349705}. |
| Top Pathways | Calcium signaling pathway, Gastric acid secretion, Neuroactive ligand-receptor interaction |
Human-CCKBR-cDNA-Clone - DC00361 from Abgent, a WuXi AppTec company
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Human Cholecystokinin-B R/CCKBR (NP_795344) VersaClone cDNA - RDC0351 from R&D Systems
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Mouse Cholecystokinin-B R/CCKBR (NP_031653) VersaClone cDNA - RDC0610 from R&D Systems
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CCKBR - MBS1271032 from MyBioSource
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Human CCKBR ORF Clone (BC000740) - CDCS417539 from Creative biogene
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