CCKBR

Gene Symbol	CCKBR
Entrez Gene	887
Alt Symbol	CCK-B, CCK2R, GASR
Species	Human
Gene Type	protein-coding
Description	cholecystokinin B receptor
Other Description	CCK-B receptor|CCK-BR|CCK2 receptor|CCK2-R|cholecystokinin-2 receptor|gastrin receptor|gastrin/cholecystokinin type B receptor
Swissprots	Q9UBV1 Q96LC6 Q9NYK7 O75824 P32239 Q16144 A8K7P9 Q92492
Accessions	AAC37528 AAD14956 BAA04759 EAW68734 EAW68735 P32239 AF239668 AAF67174 AF441129 AAN32829 AK226020 AK292064 BAF84753 AK314266 AY029770 AAK38351 AY322551 AAP84364 BC000740 AAH00740 BT006789 AAP35435 CX762706 D13305 BAA02564 DA297178 DQ335648 ABC86718 DQ335649 ABC86719 DQ335650 ABC86720 DQ335651 ABC86721 DQ890577 ABM92194 DQ893737 ABM84663 L04473 AAA35660 L07746 AAA91831 L08112 AAA35657 S70057 AAB30766 S76072 AAB33740 Y13464 XM_005253210 XP_005253267 XM_011520443 XP_011518745 NM_176875 NP_795344
Function	Receptor for gastrin and cholecystokinin. The CKK-B receptors occur throughout the central nervous system where they modulate anxiety, analgesia, arousal, and neuroleptic activity. This receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system.
Subcellular Location	Cell membrane; Multi-pass membrane protein.
Tissue Specificity	Isoform 1 is expressed in brain, pancreas, stomach, the colon cancer cell line LoVo and the T-lymphoblastoma Jurkat, but not in heart, placenta, liver, lung, skeletal muscle, kidney or the stomach cancer cell line AGS. Expressed at high levels in the small cell lung cancer cell line NCI-H510, at lower levels in NCI-H345, NCI-H69 and GLC-28 cell lines, not expressed in GLC-19 cell line. Within the stomach, expressed at high levels in the mucosa of the gastric fundus and at low levels in the antrum and duodenum. Isoform 2 is present in pancreatic cancer cells and colorectal cancer cells, but not in normal pancreas or colonic mucosa. Isoform 3 is expressed in brain, pancreas, stomach, the stomach cancer cell line AGS and the colon cancer cell line LoVo. {ECO:0000269|PubMed:10913157, ECO:0000269|PubMed:12429993, ECO:0000269|PubMed:7848914, ECO:0000269|PubMed:7887934, ECO:0000269|PubMed:8185170, ECO:0000269|PubMed:8349705}.
Top Pathways	Calcium signaling pathway, Gastric acid secretion, Neuroactive ligand-receptor interaction

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human CCKBR full length protein - ab152259 from Abcam Category Protein Source Wheat germ Species Human

Human CCKBR peptide - ab42261 from Abcam Category Peptide Prices $181.00 Sizes 100 µg Species Human

Human CCKBR peptide - ab42263 from Abcam Category Peptide Prices $181.00 Sizes 100 µg Species Human

Human CCKBR peptide - ab87366 from Abcam Category Peptide Prices $176.00 Sizes 100 µg

Human CCKBR protein fragment - ab152260 from Abcam Category Protein Prices $402.00 Sizes 10 µg Source Wheat germ Species Human

CCKBR / Cckb Antibody Blocking Peptide - LS-E25883 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

CCKBR / Cckb Antibody Blocking Peptide - LS-E23065 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

CCKBR / Cckb Antibody Blocking Peptide - LS-E28214 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 50 µg

CCKBR / Cckb Antibody Blocking Peptide - LS-E29135 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 50 µg

Cholecystokinin-B R/CCKBR Recombinant Protein - H00000887-P01 from Novus Biologicals Category Protein Species Human

Recombinant Human Cholecystokinin-B R/CCKBR Protein - H00000887-Q01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

Recombinant Human Cholecystokinin-B R/CCKBR Protein - H00000887-G01 from Novus Biologicals Category Protein Prices $569.00 Sizes 10 µg Source Wheat Germ Species Human

CCKBR blocking peptide - GTX89402-PEP from GeneTex Category Peptide Prices $239.00 Sizes 100 μg Species Human, Mouse, Rat, Bovine

CCKBR Blocking Peptide - abx062362 from Abbexa Category Peptide Species Human, Bovine, Monkey, Rabbit

CCKBR Peptide - AC21-0712-P from Abcore Category Peptide Prices $160.00 Sizes 100 µg

CCK-B Receptor - H00000887-G01 from Acris Antibodies Category Protein Prices $550.00 Sizes 10 µg Species Human

CCK-B Receptor - H00000887-P01 from Acris Antibodies Category Protein Species Human

CCK-B Receptor - H00000887-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

CCK-B Receptor - H00000887-Q01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

CCK-B Receptor - H00000887-Q02-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Species Human

CCK-B Receptor - H00000887-Q02-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Species Human

CCKBR Peptide - 45-378P from ProSci Category Peptide Prices $175.00 Sizes 100 µg Species Human, Rat

CCKBR fusion protein - ag0189 from Proteintech Group Category Protein Source E. coli-derived, PGEX-4T Species Human

Recombinant Cholecystokinin B Receptor (CCKBR) - RPB051Hu01 from Uscn Life Science Inc. Category Protein Source E.coli Species Human

ChemiScreen™ Recombinant Human CCK 2 Cholecystokinin Receptor Membrane Preparation - HTS083M from EMD Millipore Prices $596.00 Sizes 200 units Species Human

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