CCKBR

Gene Symbol CCKBR
Entrez Gene 887
Alt Symbol CCK-B, CCK2R, GASR
Species Human
Gene Type protein-coding
Description cholecystokinin B receptor
Other Description CCK-B receptor|CCK-BR|CCK2 receptor|CCK2-R|cholecystokinin-2 receptor|gastrin receptor|gastrin/cholecystokinin type B receptor
Swissprots Q9UBV1 Q96LC6 Q9NYK7 O75824 P32239 Q16144 A8K7P9 Q92492
Accessions AAC37528 AAD14956 BAA04759 EAW68734 EAW68735 P32239 AF239668 AAF67174 AF441129 AAN32829 AK226020 AK292064 BAF84753 AK314266 AY029770 AAK38351 AY322551 AAP84364 BC000740 AAH00740 BT006789 AAP35435 CX762706 D13305 BAA02564 DA297178 DQ335648 ABC86718 DQ335649 ABC86719 DQ335650 ABC86720 DQ335651 ABC86721 DQ890577 ABM92194 DQ893737 ABM84663 L04473 AAA35660 L07746 AAA91831 L08112 AAA35657 S70057 AAB30766 S76072 AAB33740 Y13464 XM_005253210 XP_005253267 XM_011520443 XP_011518745 NM_176875 NP_795344
Function Receptor for gastrin and cholecystokinin. The CKK-B receptors occur throughout the central nervous system where they modulate anxiety, analgesia, arousal, and neuroleptic activity. This receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system.
Subcellular Location Cell membrane; Multi-pass membrane protein.
Tissue Specificity Isoform 1 is expressed in brain, pancreas, stomach, the colon cancer cell line LoVo and the T-lymphoblastoma Jurkat, but not in heart, placenta, liver, lung, skeletal muscle, kidney or the stomach cancer cell line AGS. Expressed at high levels in the small cell lung cancer cell line NCI-H510, at lower levels in NCI-H345, NCI-H69 and GLC-28 cell lines, not expressed in GLC-19 cell line. Within the stomach, expressed at high levels in the mucosa of the gastric fundus and at low levels in the antrum and duodenum. Isoform 2 is present in pancreatic cancer cells and colorectal cancer cells, but not in normal pancreas or colonic mucosa. Isoform 3 is expressed in brain, pancreas, stomach, the stomach cancer cell line AGS and the colon cancer cell line LoVo. {ECO:0000269|PubMed:10913157, ECO:0000269|PubMed:12429993, ECO:0000269|PubMed:7848914, ECO:0000269|PubMed:7887934, ECO:0000269|PubMed:8185170, ECO:0000269|PubMed:8349705}.
Top Pathways Calcium signaling pathway, Gastric acid secretion, Neuroactive ligand-receptor interaction

CCK-BR CRISPR/Cas9 KO Plasmid (h) - sc-401867 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

CCK-BR HDR Plasmid (h) - sc-401867-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

CCK-BR Double Nickase Plasmid (h) - sc-401867-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

CCK-BR Double Nickase Plasmid (h2) - sc-401867-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

CCK-BR CRISPR Activation Plasmid (h) - sc-401867-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

CCK-BR CRISPR Activation Plasmid (h2) - sc-401867-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

CCK-BR Lentiviral Activation Particles (h) - sc-401867-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

CCK-BR Lentiviral Activation Particles (h2) - sc-401867-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

CCK-BR siRNA (h) - sc-43671 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

CCK-BR shRNA Plasmid (h) - sc-43671-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

CCK-BR shRNA (h) Lentiviral Particles - sc-43671-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

Cholecystokinin-B R/CCKBR RNAi - H00000887-R02 from Novus Biologicals

Category siRNA
Prices $399.00
Sizes 20 nmol
Species Reactivities Human

MISSION® esiRNA - EHU056491 from Sigma-Aldrich

Category siRNA
Prices $250.00
Sizes 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN5595 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND5595 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

MISSION® 3′UTR Lenti GoClone™ - HUTR04295 from Sigma-Aldrich

Category miRNA
Prices $350.00
Sizes hutr04295

CCKBR siRNA (Human) - CRH0623 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

CCKBR - MBS8201174 from MyBioSource

Prices $365.00, $515.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

shRNA set against Human CCKBR (NM_176875.3) - SHH257461 from Creative biogene

Category siRNA
Species Reactivities Human

CCK-BR CRISPR/Cas9 KO Plasmid (h2) - sc-401867-KO-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

CCK-BR HDR Plasmid (h2) - sc-401867-HDR-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

Human CCKBR siRNA - orb261125 from Biorbyt

Category siRNA
Prices $485.00, $629.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

CCKBR shRNA Plasmid (Human) - CHH0623 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human

CCKBR miRNA 3'UTR clone - MiUTR3H-00415 from Creative biogene

Species Reactivities Human
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