Tlr6

Gene Symbol	Tlr6
Entrez Gene	21899
Alt Symbol	-
Species	Mouse
Gene Type	protein-coding
Description	toll-like receptor 6
Other Description	-
Swissprots	Q9WTQ4 Q9EPW9
Accessions	EDL37724 EDL37725 Q9EPW9 AB020808 BAA78632 AF314636 AAG38563 AK137502 BAE23384 AK154253 BC055366 AAH55366 DQ790887 ABG78745 XM_006503857 XP_006503920 XM_006503858 XP_006503921 XM_006503859 XP_006503922 XM_006503860 XP_006503923 XM_011240721 XP_011239023 NM_011604 NP_035734
Function	Participates in the innate immune response to Gram- positive bacteria and fungi. Specifically recognizes diacylated and, to a lesser extent, triacylated lipopeptides. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Cooperates with TLR2 for the cellular activation. In complex with TLR4, promotes sterile inflammation in monocytes/macrophages in response to oxidized low- density lipoprotein (oxLDL) or amyloid-beta 42. In this context, the initial signal is provided by oxLDL- or amyloid-beta 42- binding to CD36. This event induces the formation of a heterodimer of TLR4 and TLR6, which is rapidly internalized and triggers inflammatory response, leading to the NF-kappa-B-dependent production of CXCL1, CXCL2 and CCL9 cytokines, via MYD88 signaling pathway, and CCL5 cytokine, via TICAM1 signaling pathway, as well as IL1B secretion. {ECO:0000269|PubMed:19931471, ECO:0000269|PubMed:20037584}.
Subcellular Location	Cell membrane {ECO:0000250|UniProtKB:Q9Y2C9}; Single-pass type I membrane protein. Cytoplasmic vesicle, phagosome membrane; Single-pass type I membrane protein. Note=Upon complex formation with CD36 and TLR4, internalized through dynamin-dependent endocytosis. {ECO:0000250|UniProtKB:Q9Y2C9}.
Tissue Specificity	Detected in thymus, spleen, ovary and lung.
Top Pathways	Toll-like receptor signaling pathway, Chagas disease (American trypanosomiasis), Phagosome, Tuberculosis

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones

TLR6 (E-19) - sc-5662 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Goat Clonality Polyclonal

TLR6 (S-14) - sc-5661 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Goat Clonality Polyclonal

TLR6 Antibody (418601) - MAB1533 from Novus Biologicals Prices $99.00, $249.00 Sizes 25 µg, 100 µg Host Rat Clonality Monoclonal Clone 418601

TLR6 Antibody [Unconjugated] - AF1533 from Novus Biologicals Prices $99.00, $359.00 Sizes 25 µg, 100 µg Host Goat Clonality Polyclonal

TLR6 Antibody [Biotin] - BAF1533 from Novus Biologicals Prices $390.00 Sizes 50 µg Host Goat Clonality Polyclonal

TLR6 Antibody (418601) [Allophycocyanin] - FAB1533A from Novus Biologicals Prices $339.00 Sizes 100 tests Host Rat Clonality Monoclonal Clone 418601

TLR6 Antibody (418601) [Phycoerythrin] - FAB1533P from Novus Biologicals Prices $299.00 Sizes 100 tests Host Rat Clonality Monoclonal Clone 418601

Anti-Mouse Tlr6 (C-term) antibody produced in rabbit - SAB1300203 from Sigma-Aldrich Prices $291.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

Anti-Mouse Tlr6 (N-term) antibody produced in rabbit - SAB1300202 from Sigma-Aldrich Prices $291.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

Mouse-TLR6-Antibody-C-term - AP1506c from Abgent, a WuXi AppTec company Prices $99.00, $295.00 Sizes 80 µl, 400 µl Host Rabbit Clonality Polyclonal

Mouse-TLR6-Antibody-N-term - AP1506b from Abgent, a WuXi AppTec company Prices $99.00, $295.00 Sizes 80 µl, 400 µl Host Rabbit Clonality Polyclonal

Mouse TLR6 Antibody - N-terminal region (OAAB11349) - OAAB11349 from Aviva Systems Biology Prices $289.00 Sizes 400 µl Host Rabbit Clonality Polyclonal

Mouse TLR6 Antibody - C-terminal region (OAAB11350) - OAAB11350 from Aviva Systems Biology Prices $289.00 Sizes 400 µl Host Rabbit Clonality Polyclonal

CD286 / TLR6 (N-term) antibody - AP11537PU-N from Acris Antibodies Prices $330.00 Sizes 400 µl Host Rabbit Clonality Polyclonal

CD286 / TLR6 (C-term) antibody - AP11538PU-N from Acris Antibodies Prices $330.00 Sizes 400 µl Host Rabbit Clonality Polyclonal

CD286 / TLR6 antibody - PAB3555 from Acris Antibodies Prices $420.00 Sizes 400 µl Host Rabbit Clonality Polyclonal

TLR6, Polyclonal Antibody - MBS540361 from MyBioSource Prices $390.00 Sizes 0.1 mg affinity-purified Host Rabbit Clonality Polyclonal

TLR6, Polyclonal Antibody - MBS9205577 from MyBioSource Prices $155.00, $340.00 Sizes 80 µl, 400 µl Host Rabbit Clonality Polyclonal

TLR6, Polyclonal Antibody - MBS9213258 from MyBioSource Prices $155.00, $340.00 Sizes 80 µl, 400 µl Host Rabbit Clonality Polyclonal

Mouse TLR6 antibody - orb33215 from Biorbyt Prices $187.00, $383.00 Sizes 80 μl (Trial size), 400 μl Host Rabbit Clonality Polyclonal

TLR6 Antibody (F44377) - F44377 from NSJ Bioreagent Prices $125.00, $299.00 Sizes 80 µl (In 1X PBS, pH 7.4, with 0.09% sodium azide), 400 µl (In 1X PBS, pH 7.4, with 0.09% sodium azide) Host Rabbit Clonality Polyclonal

TLR6 Antibody (F44378) - F44378 from NSJ Bioreagent Prices $125.00, $299.00 Sizes 80 µl (In 1X PBS, pH 7.4, with 0.09% sodium azide), 400 µl (In 1X PBS, pH 7.4, with 0.09% sodium azide) Host Rabbit Clonality Polyclonal

Mouse TLR6 Antibody - 58-164 from ProSci Prices $375.00 Sizes 400 µl Host Rabbit Clonality Polyclonal

Search more