| Gene Symbol | Tlr6 |
|---|---|
| Entrez Gene | 21899 |
| Alt Symbol | - |
| Species | Mouse |
| Gene Type | protein-coding |
| Description | toll-like receptor 6 |
| Other Description | - |
| Swissprots | Q9WTQ4 Q9EPW9 |
| Accessions | EDL37724 EDL37725 Q9EPW9 AB020808 BAA78632 AF314636 AAG38563 AK137502 BAE23384 AK154253 BC055366 AAH55366 DQ790887 ABG78745 XM_006503857 XP_006503920 XM_006503858 XP_006503921 XM_006503859 XP_006503922 XM_006503860 XP_006503923 XM_011240721 XP_011239023 NM_011604 NP_035734 |
| Function | Participates in the innate immune response to Gram- positive bacteria and fungi. Specifically recognizes diacylated and, to a lesser extent, triacylated lipopeptides. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Cooperates with TLR2 for the cellular activation. In complex with TLR4, promotes sterile inflammation in monocytes/macrophages in response to oxidized low- density lipoprotein (oxLDL) or amyloid-beta 42. In this context, the initial signal is provided by oxLDL- or amyloid-beta 42- binding to CD36. This event induces the formation of a heterodimer of TLR4 and TLR6, which is rapidly internalized and triggers inflammatory response, leading to the NF-kappa-B-dependent production of CXCL1, CXCL2 and CCL9 cytokines, via MYD88 signaling pathway, and CCL5 cytokine, via TICAM1 signaling pathway, as well as IL1B secretion. {ECO:0000269|PubMed:19931471, ECO:0000269|PubMed:20037584}. |
| Subcellular Location | Cell membrane {ECO:0000250|UniProtKB:Q9Y2C9}; Single-pass type I membrane protein. Cytoplasmic vesicle, phagosome membrane; Single-pass type I membrane protein. Note=Upon complex formation with CD36 and TLR4, internalized through dynamin-dependent endocytosis. {ECO:0000250|UniProtKB:Q9Y2C9}. |
| Tissue Specificity | Detected in thymus, spleen, ovary and lung. |
| Top Pathways | Toll-like receptor signaling pathway, Chagas disease (American trypanosomiasis), Phagosome, Tuberculosis |