Tlr6

Gene Symbol	Tlr6
Entrez Gene	21899
Alt Symbol	-
Species	Mouse
Gene Type	protein-coding
Description	toll-like receptor 6
Other Description	-
Swissprots	Q9WTQ4 Q9EPW9
Accessions	EDL37724 EDL37725 Q9EPW9 AB020808 BAA78632 AF314636 AAG38563 AK137502 BAE23384 AK154253 BC055366 AAH55366 DQ790887 ABG78745 XM_006503857 XP_006503920 XM_006503858 XP_006503921 XM_006503859 XP_006503922 XM_006503860 XP_006503923 XM_011240721 XP_011239023 NM_011604 NP_035734
Function	Participates in the innate immune response to Gram- positive bacteria and fungi. Specifically recognizes diacylated and, to a lesser extent, triacylated lipopeptides. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Cooperates with TLR2 for the cellular activation. In complex with TLR4, promotes sterile inflammation in monocytes/macrophages in response to oxidized low- density lipoprotein (oxLDL) or amyloid-beta 42. In this context, the initial signal is provided by oxLDL- or amyloid-beta 42- binding to CD36. This event induces the formation of a heterodimer of TLR4 and TLR6, which is rapidly internalized and triggers inflammatory response, leading to the NF-kappa-B-dependent production of CXCL1, CXCL2 and CCL9 cytokines, via MYD88 signaling pathway, and CCL5 cytokine, via TICAM1 signaling pathway, as well as IL1B secretion. {ECO:0000269|PubMed:19931471, ECO:0000269|PubMed:20037584}.
Subcellular Location	Cell membrane {ECO:0000250|UniProtKB:Q9Y2C9}; Single-pass type I membrane protein. Cytoplasmic vesicle, phagosome membrane; Single-pass type I membrane protein. Note=Upon complex formation with CD36 and TLR4, internalized through dynamin-dependent endocytosis. {ECO:0000250|UniProtKB:Q9Y2C9}.
Tissue Specificity	Detected in thymus, spleen, ovary and lung.
Top Pathways	Toll-like receptor signaling pathway, Chagas disease (American trypanosomiasis), Phagosome, Tuberculosis

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones

Toll Like Receptor 6 (TLR6), Mouse, ELISA Kit - SEA683Mu from ARP American Research Products Category ELISA Kit Prices $668.00 Sizes 96 t Sensitivity 0.125ng/mL Range 0.312-20ng/mL

Toll-like receptor 6 (TLR6), Mouse, ELISA Kit - CSB-EL023605MO from ARP American Research Products Category ELISA Kit Prices $495.00, $695.00, $696.00, $699.00 Sizes 48 t, 96 t, 5 x 96t, 10 x 96t

Toll-like receptor 6, Tlr6, Mouse, ELISA Kit - E0683m from ARP American Research Products Category ELISA Kit Prices $596.00 Sizes 96 t Range 0.312-20 ng/mL

Mouse Toll-like receptor 6(TLR6) ELISA kit - CSB-EL023605MO from Cusabio Category ELISA Kit Sensitivity Request Information Range Request Information

toll-like receptor 6, ELISA Kit - MBS935741 from MyBioSource Category ELISA Kit Prices $250.00, $495.00, $710.00, $2,705.00, $5,145.00 Sizes 24 -strip-wells (Limit 1), 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Mouse Toll-like receptor 6 ELISA Kit - abx254791 from Abbexa Category ELISA Kit Range 0.312 ng/ml - 20 ng/ml

Mouse TLR6 ELISA Kit - abx573131 from Abbexa Category ELISA Kit Sensitivity 0.125 ng/ml Range 0.313 ng/ml - 20 ng/ml

Mouse Toll-like receptor 6 (TLR6) ELISA Kit - EKC37937 from Biomatik Category ELISA Kit Prices $705.00, $2,820.00, $5,288.00 Sizes 96 t, 5x96t, 10x96t Sensitivity 19.5 pg/ml Range 78 pg/ml-5000 pg/ml

Mouse Toll-like receptor 6 ELISA Kit - EKE53072 from Biomatik Category ELISA Kit Prices $685.40, $2,912.95, $5,483.20 Sizes 96 t, 5x96t, 10x96t Range 0.312-20 ng/mL

TLR6 - EKM0874 from Nordic BioSite Sensitivity 0.188ng/ml Range 0.312-20ng/ml

TLR6 - EKM874 from Nordic BioSite Sensitivity 0.188ng/ml Range 0.312-20ng/ml

Mouse Tlr6 ELISA Kit - E070357 from Biobool Category ELISA Kit

TLR6 ELISA Kit (Mouse) (OKEH03187) - OKEH03187 from Aviva Systems Biology Category ELISA Kit Prices $425.00 Sizes 96 wells Sensitivity < 0.078 ng/mL Range 0.312 - 20 ng/mL

Mouse Toll-like receptor 6 ELISA Kit - EK2115 from Signalway Antibody Category ELISA Kit Prices $599.00 Sizes 1x96t Range 0.312-20 ng/mL

Toll Like Receptor 6 (TLR6), ELISA Kit - MBS456251 from MyBioSource Category ELISA Kit Prices $395.00, $520.00, $2,275.00, $4,420.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity 0.125ng/mL Range 0.312-20ng/mL

Toll-like receptor 6, ELISA Kit - MBS9425962 from MyBioSource Category ELISA Kit Prices $555.00 Sizes 96 tests Range 0.312-20 ng/mL

Toll-like receptor 6, ELISA Kit - MBS2886719 from MyBioSource Category ELISA Kit Prices $380.00, $500.00, $2,170.00, $3,840.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Range 0.312-20 ng/mL

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