Park7

Gene Symbol	Park7
Entrez Gene	117287
Alt Symbol	CAP1, DJ-1, Dj1, SP22
Species	Rat
Gene Type	protein-coding
Description	parkinson protein 7
Other Description	Parkinson disease (autosomal recessive, early onset) 7|contraception-associated protein 1|fertility protein SP22|parkinson disease protein 7 homolog|protein DJ-1|protein deglycase DJ-1
Swissprots	O88767
Accessions	CAX86879 CAX86880 CAX86881 EDL81193 EDL81194 EDL81195 O88767 AF157511 AAD43956 AF157512 AAD43957 AJ007291 CAA07434 BC091128 AAH91128 FM055257 FM061417 FM069664 FQ217993 FQ220895 FQ223564 FQ224480 NM_001277249 NP_001264178 NM_001277250 NP_001264179 NM_001277251 NP_001264180 NM_001277252 NP_001264181 NM_001277253 NP_001264182 NM_057143 NP_476484
Function	Protein deglycase that repairs methylglyoxal- and glyoxal-glycated amino acids and proteins, and releases repaired proteins and lactate or glycolate, respectively. Deglycates cysteines, arginines and lysines residues in proteins, and thus reactivates these proteins by reversing glycation by glyoxals. Acts on early glycation intermediates (hemithioacetals and aminocarbinols), preventing the formation of advanced glycation endproducts (AGE). Plays an important role in cell protection against oxidative stress and cell death acting as oxidative stress sensor and redox-sensitive chaperone and protease; functions probably related to its primary function. It is involved in neuroprotective mechanisms like the stabilization of NFE2L2 and PINK1 proteins, male fertility as a positive regulator of androgen signaling pathway as well as cell growth and transformation through, for instance, the modulation of NF-kappa-B signaling pathway. Its involvement in protein repair could also explain other unre
Subcellular Location	Cell membrane {ECO:0000250|UniProtKB:O88767}; Lipid-anchor {ECO:0000250|UniProtKB:O88767}. Cytoplasm {ECO:0000269|PubMed:10022524}. Membrane raft {ECO:0000269|PubMed:23847046}. Nucleus {ECO:0000269|PubMed:10022524}. Mitochondrion {ECO:0000250|UniProtKB:Q99497}. Note=Under normal conditions, located predominantly in the cytoplasm and, to a lesser extent, in the nucleus and mitochondrion. Translocates to the mitochondrion and subsequently to the nucleus in response to oxidative stress and exerts an increased cytoprotective effect against oxidative damage (By similarity). Membrane raft localization in astrocytes and neuronal cells requires palmitoylation (PubMed:23847046). {ECO:0000250|UniProtKB:Q99497, ECO:0000269|PubMed:23847046}.
Tissue Specificity	Ubiquitous. Detected on epididymal sperm. Highly expressed in testis and prostate. Detected at lower levels in heart, lung, brain, liver, kidney, seminal vesicle, caput and corpus epididymis. {ECO:0000269|PubMed:9792810}.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones

Anti-Park7 (DJ-1) (OAPC00050) - OAPC00050 from Aviva Systems Biology Prices $349.00 Sizes 100 µl Host Mouse Clonality Monoclonal Clone 4H4

Park7-DJ-1-Antibody - AN1214 from Abgent, a WuXi AppTec company Prices $335.00 Sizes 100 µl Host Mouse Clonality Monoclonal Clone 4H4

PARK7 Antibody - abx102923 from Abbexa Host Rabbit Clonality Polyclonal

Anti-Parkinson Disease Protein 7 (PARK7) - 20-5530 from ARP American Research Products Prices $409.00 Sizes 50 µg Host Rabbit Clonality Polyclonal

CAP1, Polyclonal Antibody - MBS2517248 from MyBioSource Prices $110.00, $150.00, $225.00, $360.00 Sizes 20 µl, 60 µl, 120 µl, 200 µl Host Rabbit Clonality Polyclonal

CAP1, Polyclonal Antibody - MBS2520068 from MyBioSource Prices $110.00, $150.00, $225.00, $360.00 Sizes 20 µl, 60 µl, 120 µl, 200 µl Host Rabbit Clonality Polyclonal

CAP1, Polyclonal Antibody - MBS2522437 from MyBioSource Prices $195.00, $270.00, $435.00 Sizes 60 µl, 120 µl, 200 µl Host Rabbit Clonality Polyclonal

Park7 (DJ-1), Monoclonal Antibody - MBS500040 from MyBioSource Prices $345.00 Sizes 100 µl Host Mouse Clonality Monoclonal Clone 4H4

Mouse anti-Rat Park7 (DJ-1) Monoclonal antibody [clone 5I5] - DCABY-865 from Creative Diagnostics Host Mouse Clonality Monoclonal Clone 5I5

Monoclonal Antibody to Parkinson Disease Protein 7 (PARK7) - MAL059Ra21 from Cloud-clone Host Mouse Clonality Monoclonal

Polyclonal Antibody to Parkinson Disease Protein 7 (PARK7) - PAL059Ra01 from Cloud-clone Host Rabbit Clonality Polyclonal

Biotin-Linked Antibody to Parkinson Disease Protein 7 (PARK7) - PAL059Ra71 from Cloud-clone Host Rabbit Clonality Polyclonal

DJ1 antibody - 70R-50866 from Fitzgerald Prices $395.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

CAP1, Polyclonal Antibody - MBS767478 from MyBioSource Prices $265.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

Anti-Park7/DJ-1 antibody - STJ120187 from St John's Laboratory Ltd Host Mouse Clonality Monoclonal Clone 4H4

Anti-PARK7 / DJ1 Picoband™ Antibody A00757-2 - A00757-2 from Boster Bio Prices $240.00 Sizes 1 Host Rabbit Clonality Polyclonal

Park7 Antibody / DJ-1 (R32861) - R32861 from NSJ Bioreagent Prices $299.00 Sizes 100 µg (0.5mg/ml if reconstituted with 0.2ml sterile DI water) Host Rabbit Clonality Polyclonal

Anti-PARK7--DJ1-Picoband-trade-Antibody - ABO12881 from Abgent, a WuXi AppTec company Prices $240.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

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