Park7

Gene Symbol	Park7
Entrez Gene	117287
Alt Symbol	CAP1, DJ-1, Dj1, SP22
Species	Rat
Gene Type	protein-coding
Description	parkinson protein 7
Other Description	Parkinson disease (autosomal recessive, early onset) 7|contraception-associated protein 1|fertility protein SP22|parkinson disease protein 7 homolog|protein DJ-1|protein deglycase DJ-1
Swissprots	O88767
Accessions	CAX86879 CAX86880 CAX86881 EDL81193 EDL81194 EDL81195 O88767 AF157511 AAD43956 AF157512 AAD43957 AJ007291 CAA07434 BC091128 AAH91128 FM055257 FM061417 FM069664 FQ217993 FQ220895 FQ223564 FQ224480 NM_001277249 NP_001264178 NM_001277250 NP_001264179 NM_001277251 NP_001264180 NM_001277252 NP_001264181 NM_001277253 NP_001264182 NM_057143 NP_476484
Function	Protein deglycase that repairs methylglyoxal- and glyoxal-glycated amino acids and proteins, and releases repaired proteins and lactate or glycolate, respectively. Deglycates cysteines, arginines and lysines residues in proteins, and thus reactivates these proteins by reversing glycation by glyoxals. Acts on early glycation intermediates (hemithioacetals and aminocarbinols), preventing the formation of advanced glycation endproducts (AGE). Plays an important role in cell protection against oxidative stress and cell death acting as oxidative stress sensor and redox-sensitive chaperone and protease; functions probably related to its primary function. It is involved in neuroprotective mechanisms like the stabilization of NFE2L2 and PINK1 proteins, male fertility as a positive regulator of androgen signaling pathway as well as cell growth and transformation through, for instance, the modulation of NF-kappa-B signaling pathway. Its involvement in protein repair could also explain other unre
Subcellular Location	Cell membrane {ECO:0000250|UniProtKB:O88767}; Lipid-anchor {ECO:0000250|UniProtKB:O88767}. Cytoplasm {ECO:0000269|PubMed:10022524}. Membrane raft {ECO:0000269|PubMed:23847046}. Nucleus {ECO:0000269|PubMed:10022524}. Mitochondrion {ECO:0000250|UniProtKB:Q99497}. Note=Under normal conditions, located predominantly in the cytoplasm and, to a lesser extent, in the nucleus and mitochondrion. Translocates to the mitochondrion and subsequently to the nucleus in response to oxidative stress and exerts an increased cytoprotective effect against oxidative damage (By similarity). Membrane raft localization in astrocytes and neuronal cells requires palmitoylation (PubMed:23847046). {ECO:0000250|UniProtKB:Q99497, ECO:0000269|PubMed:23847046}.
Tissue Specificity	Ubiquitous. Detected on epididymal sperm. Highly expressed in testis and prostate. Detected at lower levels in heart, lung, brain, liver, kidney, seminal vesicle, caput and corpus epididymis. {ECO:0000269|PubMed:9792810}.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones

Protein DJ-1 (PARK7), Rat, ELISA Kit - CSB-EL017454RA from ARP American Research Products Category ELISA Kit Prices $495.00, $695.00, $696.00, $699.00 Sizes 48 t, 96 t, 5 x 96t, 10 x 96t

Adenylyl Cyclase Associated Protein 1, ELISA Kit - MBS033541 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Adenylyl Cyclase Associated Protein 1, ELISA Kit - MBS034053 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Adenylyl Cyclase Associated Protein 1, ELISA Kit - MBS018439 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Adenylyl Cyclase Associated Protein 1, ELISA Kit - MBS039687 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Adenylyl Cyclase Associated Protein 1, ELISA Kit - MBS093463 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Adenylyl Cyclase Associated Protein 1, ELISA Kit - MBS034074 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Adenylyl Cyclase Associated Protein 1, ELISA Kit - MBS724509 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity 0.1 ng/mL.

Adenylyl Cyclase Associated Protein 1, ELISA Kit - MBS036909 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Adenylyl Cyclase Associated Protein 1, ELISA Kit - MBS035122 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Adenylyl Cyclase Associated Protein 1, ELISA Kit - MBS042037 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Adenylyl Cyclase Associated Protein 1, ELISA Kit - MBS724036 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Adenylyl Cyclase Associated Protein 1, ELISA Kit - MBS020560 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Adenylyl Cyclase Associated Protein 1, ELISA Kit - MBS007256 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Adenylyl Cyclase Associated Protein 1, ELISA Kit - MBS723827 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Adenylyl Cyclase Associated Protein 1, ELISA Kit - MBS079997 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Adenylyl Cyclase Associated Protein 1, ELISA Kit - MBS069246 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Adenylyl Cyclase Associated Protein 1, ELISA Kit - MBS027030 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Adenylyl Cyclase Associated Protein 1, ELISA Kit - MBS726685 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Adenylyl Cyclase Associated Protein 1, ELISA Kit - MBS027308 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity 10 pg/ml. Range 62.5 pg/ml – 2000 pg/ml.

Adenylyl Cyclase Associated Protein 1, ELISA Kit - MBS050112 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Adenylyl Cyclase Associated Protein 1, ELISA Kit - MBS018376 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Adenylyl Cyclase Associated Protein 1, ELISA Kit - MBS023497 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity 10 pg/ml. Range 62.5 pg/ml - 2000 pg/ml.

Adenylyl Cyclase Associated Protein 1, ELISA Kit - MBS034800 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity 10 pg/ml Range 62.5 pg/ml - 2000 pg/ml

Adenylyl Cyclase Associated Protein 1, ELISA Kit - MBS733428 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

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