| Gene Symbol |
Park7
|
| Entrez Gene |
117287
|
| Alt Symbol |
CAP1, DJ-1, Dj1, SP22
|
| Species |
Rat
|
| Gene Type |
protein-coding
|
| Description |
parkinson protein 7
|
| Other Description |
Parkinson disease (autosomal recessive, early onset) 7|contraception-associated protein 1|fertility protein SP22|parkinson disease protein 7 homolog|protein DJ-1|protein deglycase DJ-1
|
| Swissprots |
O88767
|
| Accessions |
CAX86879 CAX86880 CAX86881 EDL81193 EDL81194 EDL81195 O88767 AF157511 AAD43956 AF157512 AAD43957 AJ007291 CAA07434 BC091128 AAH91128 FM055257 FM061417 FM069664 FQ217993 FQ220895 FQ223564 FQ224480 NM_001277249 NP_001264178 NM_001277250 NP_001264179 NM_001277251 NP_001264180 NM_001277252 NP_001264181 NM_001277253 NP_001264182 NM_057143 NP_476484
|
| Function |
Protein deglycase that repairs methylglyoxal- and glyoxal-glycated amino acids and proteins, and releases repaired proteins and lactate or glycolate, respectively. Deglycates cysteines, arginines and lysines residues in proteins, and thus reactivates these proteins by reversing glycation by glyoxals. Acts on early glycation intermediates (hemithioacetals and aminocarbinols), preventing the formation of advanced glycation endproducts (AGE). Plays an important role in cell protection against oxidative stress and cell death acting as oxidative stress sensor and redox-sensitive chaperone and protease; functions probably related to its primary function. It is involved in neuroprotective mechanisms like the stabilization of NFE2L2 and PINK1 proteins, male fertility as a positive regulator of androgen signaling pathway as well as cell growth and transformation through, for instance, the modulation of NF-kappa-B signaling pathway. Its involvement in protein repair could also explain other unre
|
| Subcellular Location |
Cell membrane {ECO:0000250|UniProtKB:O88767}; Lipid-anchor {ECO:0000250|UniProtKB:O88767}. Cytoplasm {ECO:0000269|PubMed:10022524}. Membrane raft {ECO:0000269|PubMed:23847046}. Nucleus {ECO:0000269|PubMed:10022524}. Mitochondrion {ECO:0000250|UniProtKB:Q99497}. Note=Under normal conditions, located predominantly in the cytoplasm and, to a lesser extent, in the nucleus and mitochondrion. Translocates to the mitochondrion and subsequently to the nucleus in response to oxidative stress and exerts an increased cytoprotective effect against oxidative damage (By similarity). Membrane raft localization in astrocytes and neuronal cells requires palmitoylation (PubMed:23847046). {ECO:0000250|UniProtKB:Q99497, ECO:0000269|PubMed:23847046}.
|
| Tissue Specificity |
Ubiquitous. Detected on epididymal sperm. Highly expressed in testis and prostate. Detected at lower levels in heart, lung, brain, liver, kidney, seminal vesicle, caput and corpus epididymis. {ECO:0000269|PubMed:9792810}.
|