EFNA5

Gene Symbol EFNA5
Entrez Gene 1946
Alt Symbol AF1, EFL5, EPLG7, GLC1M, LERK7, RAGS
Species Human
Gene Type protein-coding
Description ephrin-A5
Other Description AL-1|LERK-7|eph-related receptor tyrosine kinase ligand 7
Swissprots P52803
Accessions EAW49063 EAW49064 EAW49065 P52803 AK025909 AK308672 BC075054 AAH75054 BC075055 AAH75055 U26403 AAB60377 XM_006714565 XP_006714628 XM_011543250 XP_011541552 XM_011543251 XP_011541553 NM_001962 NP_001953
Function Cell surface GPI-bound ligand for Eph receptors, a family of receptor tyrosine kinases which are crucial for migration, repulsion and adhesion during neuronal, vascular and epithelial development. Binds promiscuously Eph receptors residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Induces compartmentalized signaling within a caveolae-like membrane microdomain when bound to the extracellular domain of its cognate receptor. This signaling event requires the activity of the Fyn tyrosine kinase. Activates the EPHA3 receptor to regulate cell-cell adhesion and cytoskeletal organization. With the receptor EPHA2 may regulate lens fiber cells shape and interactions and be important for lens transparency maintenance. May function actively to stimulate axon fascicu
Subcellular Location Cell membrane {ECO:0000269|PubMed:11870224}; Lipid-anchor, GPI-anchor {ECO:0000269|PubMed:11870224}. Membrane, caveola {ECO:0000269|PubMed:11870224}; Lipid-anchor, GPI-anchor {ECO:0000269|PubMed:11870224}. Note=Compartmentalized in discrete caveolae-like membrane microdomains.
Top Pathways Axon guidance, PI3K-Akt signaling pathway, Rap1 signaling pathway

EFNA5 overexpression lysate - LY419623 from Acris Antibodies

Category Cell Lysate
Prices $280.00
Sizes 100 µg

EFNA5 293 Cell Lysate - 409183 from ABBIOTEC

Category Cell Lysate
Prices $392.00
Sizes 100 µg

Ephrin-A5 Overexpression Lysate (Native) - NBL1-10145 from Novus Biologicals

Category Cell Lysate
Prices $329.00
Sizes 100 µg
Western Blot: Ephrin A5 Overexpression Lysate (Adult Normal) [NBL1-10145] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for Ephrin A5.

EFNA5 Over-expression Lysate Product - GWB-785274 from Genway Biotech

Category Cell Lysate
Prices $346.00
Sizes 100 µg
Species Human

Rhesus Ephrin-A5 / EFNA5 HEK293 Cell Lysate (WB positive control) - 90044-C08HL-300 from Sino Biological

Category Cell Lysate
Prices $195.00
Sizes 300 µg
Species Rhesus

Rhesus Ephrin-A5 / EFNA5 HEK293 Cell Lysate (WB positive control) - 90044-C02HL-300 from Sino Biological

Category Cell Lysate
Prices $195.00
Sizes 300 µg
Species Rhesus

Panoply™ Human EFNA5 Knockdown Stable Cell Line - CSC-DC004758 from Creative biogene

Category Cell Line
Species Human
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