EFNA5

Gene Symbol	EFNA5
Entrez Gene	1946
Alt Symbol	AF1, EFL5, EPLG7, GLC1M, LERK7, RAGS
Species	Human
Gene Type	protein-coding
Description	ephrin-A5
Other Description	AL-1|LERK-7|eph-related receptor tyrosine kinase ligand 7
Swissprots	P52803
Accessions	EAW49063 EAW49064 EAW49065 P52803 AK025909 AK308672 BC075054 AAH75054 BC075055 AAH75055 U26403 AAB60377 XM_006714565 XP_006714628 XM_011543250 XP_011541552 XM_011543251 XP_011541553 NM_001962 NP_001953
Function	Cell surface GPI-bound ligand for Eph receptors, a family of receptor tyrosine kinases which are crucial for migration, repulsion and adhesion during neuronal, vascular and epithelial development. Binds promiscuously Eph receptors residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Induces compartmentalized signaling within a caveolae-like membrane microdomain when bound to the extracellular domain of its cognate receptor. This signaling event requires the activity of the Fyn tyrosine kinase. Activates the EPHA3 receptor to regulate cell-cell adhesion and cytoskeletal organization. With the receptor EPHA2 may regulate lens fiber cells shape and interactions and be important for lens transparency maintenance. May function actively to stimulate axon fascicu
Subcellular Location	Cell membrane {ECO:0000269|PubMed:11870224}; Lipid-anchor, GPI-anchor {ECO:0000269|PubMed:11870224}. Membrane, caveola {ECO:0000269|PubMed:11870224}; Lipid-anchor, GPI-anchor {ECO:0000269|PubMed:11870224}. Note=Compartmentalized in discrete caveolae-like membrane microdomains.
Top Pathways	Axon guidance, PI3K-Akt signaling pathway, Rap1 signaling pathway

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human EFNA5 ORF clone(NM_001962.2) - CDCH017101 from Creative Biomart Species Human Accession NM_001962.2

Human EFNA5 ORF Clone(NM_001962.2) - CDCL161967 from Creative Biomart Species Human Accession NM_001962.2

Human Ephrin-A5/EFNA5 Gene ORF cDNA clone in cloning vector - HG10192-M from Sino Biological Species Human

Human Ephrin-A5/EFNA5 Gene ORF cDNA clone expression plasmid, C-HA tag - HG10192-CY from Sino Biological Species Human

Human Ephrin-A5/EFNA5 Gene ORF cDNA clone expression plasmid, C-His tag - HG10192-CH from Sino Biological Species Human

Human Ephrin-A5/EFNA5 Gene ORF cDNA clone expression plasmid, N-Flag tag - HG10192-NF from Sino Biological Species Human

Human Ephrin-A5/EFNA5 Gene ORF cDNA clone expression plasmid, C-Flag tag - HG10192-CF from Sino Biological Species Human

Human Ephrin-A5/EFNA5 Gene ORF cDNA clone expression plasmid, N-HA tag - HG10192-NY from Sino Biological Species Human

Human Ephrin-A5/EFNA5 Gene ORF cDNA clone expression plasmid, N-Myc tag - HG10192-NM from Sino Biological Species Human

Human Ephrin-A5/EFNA5 Gene ORF cDNA clone expression plasmid, C-Myc tag - HG10192-CM from Sino Biological Species Human

Human Ephrin-A5/EFNA5 Gene ORF cDNA clone expression plasmid, C-GFPSpark tag - HG10192-ACG from Sino Biological Species Human

Human Ephrin-A5/EFNA5 Gene ORF cDNA clone expression plasmid, C-Flag tag - HG10192-M-F from Sino Biological Species Human

Human EphrinA5 Gene cDNA Clone (full-length ORF Clone), expression ready, untagged - HG10192-M-N from Sino Biological Species Human Accession NM_001962.2

Human Ephrin-A5/EFNA5 Gene ORF cDNA clone expression plasmid, C-OFPSpark tag - HG10192-ACR from Sino Biological Species Human

Human Ephrin-A5/EFNA5 Gene ORF cDNA clone expression plasmid, N-His tag - HG10192-NH from Sino Biological Species Human

Human Ephrin-A5/EFNA5 Gene ORF cDNA clone expression plasmid - HG10192-UT from Sino Biological Species Human

Human EphrinA5 ORF clone(NM_001962.2) - CDCL184083 from Creative biogene Species Human

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