EFNA5
| Gene Symbol | EFNA5 |
|---|---|
| Entrez Gene | 1946 |
| Alt Symbol | AF1, EFL5, EPLG7, GLC1M, LERK7, RAGS |
| Species | Human |
| Gene Type | protein-coding |
| Description | ephrin-A5 |
| Other Description | AL-1|LERK-7|eph-related receptor tyrosine kinase ligand 7 |
| Swissprots | P52803 |
| Accessions | EAW49063 EAW49064 EAW49065 P52803 AK025909 AK308672 BC075054 AAH75054 BC075055 AAH75055 U26403 AAB60377 XM_006714565 XP_006714628 XM_011543250 XP_011541552 XM_011543251 XP_011541553 NM_001962 NP_001953 |
| Function | Cell surface GPI-bound ligand for Eph receptors, a family of receptor tyrosine kinases which are crucial for migration, repulsion and adhesion during neuronal, vascular and epithelial development. Binds promiscuously Eph receptors residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Induces compartmentalized signaling within a caveolae-like membrane microdomain when bound to the extracellular domain of its cognate receptor. This signaling event requires the activity of the Fyn tyrosine kinase. Activates the EPHA3 receptor to regulate cell-cell adhesion and cytoskeletal organization. With the receptor EPHA2 may regulate lens fiber cells shape and interactions and be important for lens transparency maintenance. May function actively to stimulate axon fascicu |
| Subcellular Location | Cell membrane {ECO:0000269|PubMed:11870224}; Lipid-anchor, GPI-anchor {ECO:0000269|PubMed:11870224}. Membrane, caveola {ECO:0000269|PubMed:11870224}; Lipid-anchor, GPI-anchor {ECO:0000269|PubMed:11870224}. Note=Compartmentalized in discrete caveolae-like membrane microdomains. |
| Top Pathways | Axon guidance, PI3K-Akt signaling pathway, Rap1 signaling pathway |
ephrin-A5 CRISPR/Cas9 KO Plasmid (h) - sc-402127 from Santa Cruz Biotechnology
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ephrin-A5 HDR Plasmid (h) - sc-402127-HDR from Santa Cruz Biotechnology
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ephrin-A5 Double Nickase Plasmid (h) - sc-402127-NIC from Santa Cruz Biotechnology
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ephrin-A5 Double Nickase Plasmid (h2) - sc-402127-NIC-2 from Santa Cruz Biotechnology
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ephrin-A5 CRISPR Activation Plasmid (h) - sc-402127-ACT from Santa Cruz Biotechnology
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ephrin-A5 CRISPR Activation Plasmid (h2) - sc-402127-ACT-2 from Santa Cruz Biotechnology
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ephrin-A5 Lentiviral Activation Particles (h) - sc-402127-LAC from Santa Cruz Biotechnology
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ephrin-A5 Lentiviral Activation Particles (h2) - sc-402127-LAC-2 from Santa Cruz Biotechnology
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ephrin-A5 siRNA (h) - sc-39434 from Santa Cruz Biotechnology
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ephrin-A5 shRNA Plasmid (h) - sc-39434-SH from Santa Cruz Biotechnology
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ephrin-A5 shRNA (h) Lentiviral Particles - sc-39434-V from Santa Cruz Biotechnology
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Ephrin-A5 RNAi - H00001946-R01 from Novus Biologicals
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MISSION® esiRNA - EHU045701 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN7698 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND7698 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR05144 from Sigma-Aldrich
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EFNA5 siRNA (Human) - CRH1343 from Cohesion Biosciences
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EFNA5 - MBS8211289 from MyBioSource
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shRNA set against Human EFNA5 (NM_001962.2) - SHH283669 from Creative biogene
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Human EFNA5 siRNA - orb261845 from Biorbyt
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EFNA5 shRNA Plasmid (Human) - CHH1343 from Cohesion Biosciences
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